Cell-Selective Cytotoxicity of a Fluorescent Rhodium Metalloinsertor Conjugate Results from Irreversible DNA Damage at Base Pair Mismatches.
Antineoplastic Agents
/ chemical synthesis
Carbocyanines
/ chemistry
Cell Proliferation
/ drug effects
Cell Survival
/ drug effects
Coordination Complexes
/ chemical synthesis
DNA Damage
DNA Mismatch Repair
/ drug effects
Fluorescent Dyes
/ chemical synthesis
HCT116 Cells
Humans
Molecular Structure
Optical Imaging
Rhodium
/ chemistry
Journal
Biochemistry
ISSN: 1520-4995
Titre abrégé: Biochemistry
Pays: United States
ID NLM: 0370623
Informations de publication
Date de publication:
11 02 2020
11 02 2020
Historique:
pubmed:
23
1
2020
medline:
28
7
2020
entrez:
23
1
2020
Statut:
ppublish
Résumé
Up to 20% of solid tumors are characterized by DNA mismatch repair (MMR) deficiency and microsatellite instability that confer resistance to standard of care chemotherapy. MMR-deficient cancers have an increased mutation rate, and DNA mismatches accumulate as part of these cancers. We previously described a class of compounds, rhodium metalloinsertors, that bind DNA mismatches with high specificity and selectivity and have potential as targeted therapy. [Rh(chrysi)(phen)(PPO)]
Identifiants
pubmed: 31967788
doi: 10.1021/acs.biochem.9b01037
doi:
Substances chimiques
Antineoplastic Agents
0
Carbocyanines
0
Coordination Complexes
0
Fluorescent Dyes
0
cyanine dye 3
0
Rhodium
DMK383DSAC
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM