Small Molecule Inhibitor of ATPase Activity of HSP70 as a Broad-Spectrum Inhibitor against Flavivirus Infections.

Adenosine Triphosphatases / antagonists & inhibitors Animals Benzamides / therapeutic use HSP70 Heat-Shock Proteins / antagonists & inhibitors Imidazoles / therapeutic use Immunity, Innate Mice Zika Virus Infection / drug therapy
Apoptozole Zika virus antiviral flavivirus innate immunity

Journal

ACS infectious diseases
ISSN: 2373-8227
Titre abrégé: ACS Infect Dis
Pays: United States
ID NLM: 101654580

Informations de publication

Date de publication:
08 05 2020
Historique:
pubmed: 23 1 2020
medline: 3 6 2021
entrez: 23 1 2020
Statut: ppublish

Résumé

Flaviviruses including Zika virus, Dengue virus, Japanese Encephalitis virus, and Yellow Fever virus cause heavy burdens to public health around the world. No specific antiviral drug is available in the clinic against these flavivirus infections. Heat-shock protein 70 (HSP70) has recently been proven to be a promising antiviral target against Zika virus and Dengue virus. Here, we report that Apoptozole, a small molecule inhibitor of ATPase activity of HSP70, has broad-spectrum anti-flavivirus potential. The mode of action analysis revealed that Apoptozole acted at the post-entry step. Transcriptome analysis revealed that genes related to cholesterol metabolism, fatty acid synthesis, and innate immunity were differentially expressed after treatment with Apoptozole.

Identifiants

DOI: 10.1021/acsinfecdis.9b00376 PMID: 31967789
pubmed: 31967789
doi: 10.1021/acsinfecdis.9b00376
doi:

Substances chimiques

Benzamides 0
HSP70 Heat-Shock Proteins 0
Imidazoles 0
apoptozole 0
Adenosine Triphosphatases EC 3.6.1.-

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

832-843

Auteurs

Jingjing Yang (J)

National Engineering Research Center for the Emergency Drug, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China.

Yongfen Xu (Y)

CAS Key Laboratory of Molecular Virology and Immunology, Unit of Viral Hepatitis, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China.

Yunzheng Yan (Y)

National Engineering Research Center for the Emergency Drug, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China.

Wei Li (W)

National Engineering Research Center for the Emergency Drug, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China.

Lei Zhao (L)

National Engineering Research Center for the Emergency Drug, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China.

Qingsong Dai (Q)

National Engineering Research Center for the Emergency Drug, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China.

Yuexiang Li (Y)

National Engineering Research Center for the Emergency Drug, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China.

Song Li (S)

National Engineering Research Center for the Emergency Drug, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China.

Jin Zhong (J)

CAS Key Laboratory of Molecular Virology and Immunology, Unit of Viral Hepatitis, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China.

Ruiyuan Cao (R)

National Engineering Research Center for the Emergency Drug, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China.

Wu Zhong (W)

National Engineering Research Center for the Emergency Drug, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China.
ORCID: 0000-0002-0536-620X

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Acid anhydride hydrolases › Adenosine triphosphatases › Small Molecule Inhibitor of ATPase Activity of...
questionsmedicales.fr › Eucaryotes › Animaux › Small Molecule Inhibitor of ATPase Activity of...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Benzoates › Benzamides › Small Molecule Inhibitor of ATPase Activity of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Chaperons moléculaires › Protéines du choc thermique › Protéines du choc thermique HSP70 › Small Molecule Inhibitor of ATPase Activity of...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Imidazoles › Small Molecule Inhibitor of ATPase Activity of...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immunité innée › Small Molecule Inhibitor of ATPase Activity of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Small Molecule Inhibitor of ATPase Activity of...
questionsmedicales.fr › Infection › Maladies virales › Infections à virus à ARN › Infections à Flaviviridae › Infections à flavivirus › Infection par le virus Zika › Small Molecule Inhibitor of ATPase Activity of...