Case Report on: Very Early Afterdepolarizations in HiPSC-Cardiomyocytes-An Artifact by Big Conductance Calcium Activated Potassium Current (I

KCa1.1 Maxi-K big conductance calcium activated potassium channel (BK) human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) iPS cells iberiotoxin long QT syndrome slo1 stem cells

Journal

Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052

Informations de publication

Date de publication:
20 01 2020
Historique:
received: 28 10 2019
revised: 16 12 2019
accepted: 15 01 2020
entrez: 24 1 2020
pubmed: 24 1 2020
medline: 7 1 2021
Statut: epublish

Résumé

Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) represent an unlimited source of human CMs that could be a standard tool in drug research. However, there is concern whether hiPSC-CMs express all cardiac ion channels at physiological level and whether they might express non-cardiac ion channels. In a control hiPSC line, we found large, "noisy" outward K

Identifiants

pubmed: 31968557
pii: cells9010253
doi: 10.3390/cells9010253
pmc: PMC7017352
pii:
doi:

Substances chimiques

Peptides 0
Potassium Channels, Calcium-Activated 0
iberiotoxin 773HER9B6T

Types de publication

Case Reports Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Références

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Auteurs

András Horváth (A)

Institute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
DZHK (German Center for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany.
Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Szeged, 6721 Szeged, Hungary.

Torsten Christ (T)

Institute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
DZHK (German Center for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany.

Jussi T Koivumäki (JT)

BioMediTech, Faculty of Medicine and Health Technology, Tampere University, 33520 Tampere, Finland.

Maksymilian Prondzynski (M)

Institute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
DZHK (German Center for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany.

Antonia T L Zech (ATL)

Institute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
DZHK (German Center for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany.

Michael Spohn (M)

Bioinformatics Core, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.

Umber Saleem (U)

Institute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
DZHK (German Center for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany.

Ingra Mannhardt (I)

Institute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
DZHK (German Center for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany.

Bärbel Ulmer (B)

Institute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
DZHK (German Center for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany.

Evaldas Girdauskas (E)

DZHK (German Center for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany.
Department of Cardiovascular Surgery, University Heart Center, 20246 Hamburg, Germany.

Christian Meyer (C)

Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Szeged, 6721 Szeged, Hungary.
Department of Cardiology-Electrophysiology, University Heart Center, 20246 Hamburg, Germany.

Arne Hansen (A)

Institute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
DZHK (German Center for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany.

Thomas Eschenhagen (T)

Institute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
DZHK (German Center for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany.

Marc D Lemoine (MD)

Institute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
DZHK (German Center for Cardiovascular Research), Partner Site Hamburg/Kiel/Lübeck, 20246 Hamburg, Germany.
Department of Cardiology-Electrophysiology, University Heart Center, 20246 Hamburg, Germany.

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