Metabolic factors and hip fracture risk in a large Austrian cohort study.
Body mass index
Hip fractures
Metabolic syndrome
Serum cholesterol
Triglycerides
Vorarlberg Health Monitoring and Prevention Program
Journal
Bone reports
ISSN: 2352-1872
Titre abrégé: Bone Rep
Pays: United States
ID NLM: 101646176
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
received:
12
09
2019
revised:
07
01
2020
accepted:
10
01
2020
entrez:
24
1
2020
pubmed:
24
1
2020
medline:
24
1
2020
Statut:
epublish
Résumé
To explore the association of incident hip fractures with metabolic syndrome (MetS) and its single components, we designed a prospective cohort study of hip fracture incidence among 117,053 participants of a population-based health surveillance program in Vorarlberg, the westernmost Austrian province. Incident hip fractures were recorded between 5 and 10 years after inclusion at baseline from 2003 to 2009. Applying Cox proportional hazard models for each MetS component and for a composite z-score for MetS, hazards for fracture were estimated in quintiles, as continuous z-score variables, and as pathological cut off values. Mean age was 50.1 ± 15.6 years at baseline, 5-10 years after which 947 incident hip fractures occurred. An association of a higher composite MetS score with decreased hip fracture risk was observed in women (HR 0.80, 95%-CI 0.88-0.96,
Identifiants
pubmed: 31970265
doi: 10.1016/j.bonr.2020.100244
pii: S2352-1872(20)30003-6
pii: 100244
pmc: PMC6965713
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100244Informations de copyright
© 2020 Published by Elsevier Inc.
Déclaration de conflit d'intérêts
Kilian Rapp has taken part in an expert board and lecture for Amgen. Erlangga Dominic, Wolfgang Brozek, Raphael Simon Peter, Ella Fromm, Hanno Ulmer, Hans Concin, and Gabriele Nagel declare that they have no disclosures and no conflict of interest.
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