Effect of Combined Prenatal and Adult Benzophenone-3 Dermal Exposure on Factors Regulating Neurodegenerative Processes, Blood Hormone Levels, and Hematological Parameters in Female Rats.
Administration, Cutaneous
Animals
Apoptosis
/ drug effects
Apoptosis Regulatory Proteins
/ drug effects
Benzophenones
/ administration & dosage
Female
Frontal Lobe
/ drug effects
Glutamic Acid
/ metabolism
Gonadal Steroid Hormones
/ blood
Hippocampus
/ drug effects
Rats, Sprague-Dawley
Receptors, Aryl Hydrocarbon
/ metabolism
Receptors, Estrogen
/ metabolism
Receptors, Progesterone
/ metabolism
Sunscreening Agents
/ administration & dosage
Thyroid Hormones
/ blood
Benzophenone-3
Frontal cortex
Glutamate
Hematological parameters
Hippocampus
Neurotoxicity
Thyroid hormones
Journal
Neurotoxicity research
ISSN: 1476-3524
Titre abrégé: Neurotox Res
Pays: United States
ID NLM: 100929017
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
received:
07
10
2019
accepted:
08
01
2020
revised:
19
12
2019
pubmed:
24
1
2020
medline:
15
12
2020
entrez:
24
1
2020
Statut:
ppublish
Résumé
Benzophenone-3 (BP-3), the most widely used UV chemical filter, is absorbed well through the skin and gastrointestinal tract and can affect some body functions, including the survival of nerve cells. Previously, we showed that BP-3 evoked a neurotoxic effect in male rats, but since the effects of this compound are known to depend on gender, the aim of the present study was to show the concentration and potential neurotoxic action of this compound in the female rat brain. BP-3 was administered dermally to female rats during pregnancy, and then in the 7th and 8th weeks of age to their female offspring. The effect of BP-3 exposure on short-term and spatial memory, its concentrations in blood, the liver, the frontal cortex, and the hippocampus, and the effect on selected markers of brain damage were determined. Also, the impact of BP-3 on sex and thyroid hormone levels in blood and hematological parameters was examined. It has been found that this compound was present in blood and brain structures in females at a lower concentration than in males. BP-3 in both examined brain structures increased extracellular glutamate concentration and enhanced lipid peroxidation, but did not induce the apoptotic process. The tested compound also evoked hyperthyroidism and decreased the blood progesterone level and the number of erythrocytes. The presented data indicated that, after the same exposure to BP-3, this compound was at a lower concentration in the female brain than in that of the males. Although BP-3 did not induce apoptosis in the hippocampus and frontal cortex, the increased extracellular glutamate concentration and lipid peroxidation, as well as impaired spatial memory, suggested that this compound also had adverse effects in the female brain yet was weaker than in males. In contrast to the weaker effects of the BP-3 on females than the brain of males, this compound affected the endocrine system and evoked a disturbance in hematological parameters more strongly than in male rats.
Identifiants
pubmed: 31970650
doi: 10.1007/s12640-020-00163-7
pii: 10.1007/s12640-020-00163-7
pmc: PMC7062666
doi:
Substances chimiques
Apoptosis Regulatory Proteins
0
Benzophenones
0
Gonadal Steroid Hormones
0
Receptors, Aryl Hydrocarbon
0
Receptors, Estrogen
0
Receptors, Progesterone
0
Sunscreening Agents
0
Thyroid Hormones
0
Glutamic Acid
3KX376GY7L
oxybenzone
95OOS7VE0Y
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
683-701Subventions
Organisme : This research was funded by grant no. 2014/15/B/NZ7/00892 from the National Science Centre of Poland.
ID : grant no. 2014/15/B/NZ7/00892
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