Association Between Life-Course Obesity and Frailty in Older Adults: Findings in the GAZEL Cohort.
Journal
Obesity (Silver Spring, Md.)
ISSN: 1930-739X
Titre abrégé: Obesity (Silver Spring)
Pays: United States
ID NLM: 101264860
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
received:
24
05
2019
accepted:
24
09
2019
entrez:
24
1
2020
pubmed:
24
1
2020
medline:
29
8
2020
Statut:
ppublish
Résumé
This study aimed to assess the relationship between weight history during adulthood and frailty in late life in men and women participating in the GAZEL (GAZ and ELectricité) cohort. This cohort study included 8,751 men and 3,033 women (aged 61 to 76 years) followed up since 1989. Modified Fried's frailty criteria (weakness, fatigue, unintentional weight loss, low physical activity, and impaired mobility) were assessed in 2015. Reported BMI was determined each year to characterize: obesity status in 2015, obesity duration over the 1990 to 2015 period, and trajectories of BMI. Associations between frailty and weight history were assessed using multinomial regression. In 2015, 12% of men had obesity, 1.8% severe obesity, and 0.4% morbid obesity; for women, these percentages were 11%, 2.2%, and 0.8%, respectively. Individuals with obesity were more likely to be frail than those with normal BMI and the risk of frailty increased with each additional year of obesity (adjusted odds ratio 1.04 [1.00-1.08] for men and 1.07 [1.02-1.13] for women). Trajectories of BMI revealed that both long-term obesity and onset of obesity in late adulthood were associated with frailty. Current and past obesity appear to be important determinants of frailty. Early weight management may be beneficial in old age.
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
388-396Subventions
Organisme : Electricité de France-Gaz de France (EDF-GDF)and INSERM
Pays : International
Organisme : Agence nationale de la recherche
ID : ANR; ANR-08-BLAN-0028
Pays : International
Organisme : Agence française de sécurité sanitaire de l'environnement et du travail
ID : AFSSET; EST -2008/1/35
Pays : International
Informations de copyright
© 2020 The Obesity Society.
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