A lysosome-targeted near-infrared fluorescent probe for imaging of acid phosphatase in living cells.

Acid Phosphatase / analysis Biocatalysis Fluorescent Dyes / chemistry HeLa Cells Humans Indoles / chemistry Infrared Rays Lysosomes / enzymology Molecular Structure Optical Imaging Thioxanthenes / chemistry

Journal

Organic & biomolecular chemistry
ISSN: 1477-0539
Titre abrégé: Org Biomol Chem
Pays: England
ID NLM: 101154995

Informations de publication

Date de publication:
14 02 2020
Historique:
pubmed: 24 1 2020
medline: 24 9 2020
entrez: 24 1 2020
Statut: ppublish

Résumé

Fluorescent probes for the detection of acid phosphatases (ACP) are important in the investigation of the pathology and diagnosis of diseases. We reported a lysosome-targeted near-infrared (NIR) fluorescent probe SHCy-P based on a novel NIR-emitting thioxanthene-indolium dye for the detection of ACP. The probe showed a long wavelength fluorescence emission at λ

Identifiants

DOI: 10.1039/c9ob02188d PMID: 31971197
pubmed: 31971197
doi: 10.1039/c9ob02188d
doi:

Substances chimiques

Fluorescent Dyes 0
Indoles 0
Thioxanthenes 0
Acid Phosphatase EC 3.1.3.2

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1148-1154

Auteurs

Songtao Cai (S)

School of Materials Science and Engineering, Harbin Institute of Technology, Harbin 150001, China.

Chang Liu (C)

Tianjin Key Laboratory for Photoelectric Materials and Devices, and Key Laboratory of Display Materials & Photoelectric Devices, Ministry of Education, School of Materials Science & Engineering, Tianjin University of Technology, Tianjin 300384, China.

Xiaojie Jiao (X)

Tianjin Key Laboratory for Photoelectric Materials and Devices, and Key Laboratory of Display Materials & Photoelectric Devices, Ministry of Education, School of Materials Science & Engineering, Tianjin University of Technology, Tianjin 300384, China.

Song He (S)

Tianjin Key Laboratory for Photoelectric Materials and Devices, and Key Laboratory of Display Materials & Photoelectric Devices, Ministry of Education, School of Materials Science & Engineering, Tianjin University of Technology, Tianjin 300384, China.

Liancheng Zhao (L)

School of Materials Science and Engineering, Harbin Institute of Technology, Harbin 150001, China.

Xianshun Zeng (X)

School of Materials Science and Engineering, Harbin Institute of Technology, Harbin 150001, China and Tianjin Key Laboratory for Photoelectric Materials and Devices, and Key Laboratory of Display Materials & Photoelectric Devices, Ministry of Education, School of Materials Science & Engineering, Tianjin University of Technology, Tianjin 300384, China.
ORCID: 0000-0001-7761-0198

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Classifications MeSH

questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Phosphoric monoester hydrolases › Acid phosphatase › A lysosome-targeted near-infrared fluorescent...
questionsmedicales.fr › Métabolisme › Biocatalyse › A lysosome-targeted near-infrared fluorescent...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits chimiques de laboratoire › Indicateurs et réactifs › Luminescents › Colorants fluorescents › A lysosome-targeted near-infrared fluorescent...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules HeLa › A lysosome-targeted near-infrared fluorescent...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A lysosome-targeted near-infrared fluorescent...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Indoles › A lysosome-targeted near-infrared fluorescent...
questionsmedicales.fr › Environnement et santé publique › Environnement › Concepts météorologiques › Atmosphère › Temps (météorologie) › Lumière du soleil › Rayons infrarouges › A lysosome-targeted near-infrared fluorescent...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Vésicules cytoplasmiques › Lysosomes › A lysosome-targeted near-infrared fluorescent...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › A lysosome-targeted near-infrared fluorescent...
questionsmedicales.fr › Techniques d'investigation › Imagerie optique › A lysosome-targeted near-infrared fluorescent...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérocycliques 3 noyaux › Xanthènes › Thioxanthènes › A lysosome-targeted near-infrared fluorescent...