Kidney failure, arterial hypertension and left ventricular hypertrophy in rats with loss of function mutation of SOD3.

Animals Blood Pressure Hypertension / genetics Hypertrophy, Left Ventricular Kidney Loss of Function Mutation Mutation Rats Rats, Inbred Dahl Renal Insufficiency, Chronic / genetics Superoxide Dismutase / genetics
Chronic kidney disease Extracellular SOD Hypertension Hypertrophy Oxidative stress

Journal

Free radical biology & medicine
ISSN: 1873-4596
Titre abrégé: Free Radic Biol Med
Pays: United States
ID NLM: 8709159

Informations de publication

Date de publication:
20 05 2020
Historique:
received: 05 11 2019
revised: 18 01 2020
accepted: 18 01 2020
pubmed: 24 1 2020
medline: 22 6 2021
entrez: 24 1 2020
Statut: ppublish

Résumé

Chronic kidney disease (CKD) poses a considerable medical and public health challenge, and the Dahl/Salt Sensitive (Dahl/SS) strain is often used for CKD study. Extracellular superoxide dismutase (SOD3) is important for removing extracellular superoxide anions and is highly expressed in renal tissue. Using a novel rat strain with loss-of-function mutation of SOD3 created by replacing glutamate 124 of SOD3 with aspartic acid (SOD3

Identifiants

DOI: 10.1016/j.freeradbiomed.2020.01.023 PMID: 31972339
pubmed: 31972339
pii: S0891-5849(19)31433-9
doi: 10.1016/j.freeradbiomed.2020.01.023
pii:
doi:

Substances chimiques

Sod3 protein, rat EC 1.15.1.1
Superoxide Dismutase EC 1.15.1.1

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

787-796

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that there are no conflicts of interest.

Auteurs

Haipeng Guo (H)

Lillehei Heart Institute and the Cardiovascular Division, University of Minnesota, Minneapolis, MN55455, USA; Department of Critical Care Medicine, Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Qilu Hospital of Shandong University, Jinan, China.

Dachun Xu (D)

Lillehei Heart Institute and the Cardiovascular Division, University of Minnesota, Minneapolis, MN55455, USA; Cardiovascular Department, Shanghai Tenth People's Hospital, Tongji University, School of Medicine, Shanghai, China.

Marcos Kuroki (M)

Heart and Vascular Institute, Penn State College of Medicine, Hershey, PA, USA.

Zhongbing Lu (Z)

Lillehei Heart Institute and the Cardiovascular Division, University of Minnesota, Minneapolis, MN55455, USA; College of Life Science, University of Chinese Academy of Sciences, Beijing, 100049, China.

Xin Xu (X)

Shanghai Anti-doping Laboratory, Shanghai University of Sport, Shanghai, 200438, China. Electronic address: xxu2000@outlook.com.

Aron Geurts (A)

Human and Molecular Genetics Center, Cardiovascular Center, Department of Physiology, Medical College of Wisconsin, USA.

John W Osborn (JW)

Department of Surgery, University of Minnesota, USA.

Yingjie Chen (Y)

Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS39216, USA. Electronic address: ychen2@umc.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Kidney failure, arterial hypertension and left...
questionsmedicales.fr › Phénomènes physiologiques respiratoires et circulatoires › Phénomènes physiologiques cardiovasculaires › Hémodynamique › Pression sanguine › Kidney failure, arterial hypertension and left...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Hypertension artérielle › Kidney failure, arterial hypertension and left...
questionsmedicales.fr › États, signes et symptômes pathologiques › États anatomopathologiques › Hypertrophie › Cardiomégalie › Hypertrophie ventriculaire gauche › Kidney failure, arterial hypertension and left...
questionsmedicales.fr › Appareil urogénital › Voies urinaires › Rein › Kidney failure, arterial hypertension and left...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Mutation perte de fonction › Kidney failure, arterial hypertension and left...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Kidney failure, arterial hypertension and left...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Kidney failure, arterial hypertension and left...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Lignées consanguines de rats › Rats de lignée Dahl › Kidney failure, arterial hypertension and left...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Maladie chronique › Insuffisance rénale chronique › Kidney failure, arterial hypertension and left...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Superoxide dismutase › Kidney failure, arterial hypertension and left...