Reduction in Global Myocardial Glucose Metabolism in Subjects With 1-Hour Postload Hyperglycemia and Impaired Glucose Tolerance.
Adult
Blood Glucose
/ metabolism
Carbohydrate Metabolism
Diabetes Mellitus, Type 2
/ etiology
Down-Regulation
Fasting
/ metabolism
Female
Glucose
/ metabolism
Glucose Clamp Technique
Glucose Intolerance
/ blood
Glucose Tolerance Test
/ methods
Humans
Hyperglycemia
/ blood
Insulin
/ metabolism
Insulin Resistance
/ physiology
Male
Middle Aged
Myocardium
/ metabolism
Risk Factors
Time Factors
Journal
Diabetes care
ISSN: 1935-5548
Titre abrégé: Diabetes Care
Pays: United States
ID NLM: 7805975
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
04
10
2019
accepted:
16
12
2019
pubmed:
25
1
2020
medline:
15
12
2020
entrez:
25
1
2020
Statut:
ppublish
Résumé
Impaired insulin-stimulated myocardial glucose uptake has occurred in patients with type 2 diabetes with or without coronary artery disease. Whether cardiac insulin resistance is present remains uncertain in subjects at risk for type 2 diabetes, such as individuals with impaired glucose tolerance (IGT) or those with normal glucose tolerance (NGT) and 1-h postload glucose ≥155 mg/dL during an oral glucose tolerance test (NGT 1-h high). This issue was examined in this study. The myocardial metabolic rate of glucose (MRGlu) was measured by using dynamic After adjusting for age, sex, and BMI, both subjects with NGT 1-h high (23.7 ± 6.4 mmol/min/100 mg; This study shows that myocardial insulin resistance is an early defect that is already detectable in individuals with dysglycemic conditions associated with an increased risk of type 2 diabetes, such as IGT and NGT 1-h high.
Identifiants
pubmed: 31974102
pii: dc19-1975
doi: 10.2337/dc19-1975
doi:
Substances chimiques
Blood Glucose
0
Insulin
0
Glucose
IY9XDZ35W2
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
669-676Informations de copyright
© 2020 by the American Diabetes Association.