Type I Interferon Regulates a Coordinated Gene Network to Enhance Cytotoxic T Cell-Mediated Tumor Killing.
Animals
Breast Neoplasms
/ genetics
Cell Proliferation
/ genetics
Female
Gene Expression Regulation, Neoplastic
/ genetics
Gene Regulatory Networks
/ immunology
Humans
Interferon Type I
/ genetics
Mice
STAT1 Transcription Factor
/ genetics
STAT2 Transcription Factor
/ genetics
T-Lymphocytes
/ immunology
Transcription Factors
/ genetics
Ubiquitin-Activating Enzymes
/ genetics
Ubiquitins
/ genetics
Journal
Cancer discovery
ISSN: 2159-8290
Titre abrégé: Cancer Discov
Pays: United States
ID NLM: 101561693
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
28
05
2019
revised:
15
11
2019
accepted:
17
01
2020
pubmed:
25
1
2020
medline:
10
6
2021
entrez:
25
1
2020
Statut:
ppublish
Résumé
Type I interferons (IFN), which activate many IFN-stimulated genes (ISG), are known to regulate tumorigenesis. However, little is known regarding how various ISGs coordinate with one another in developing antitumor effects. Here, we report that the ISG
Identifiants
pubmed: 31974171
pii: 2159-8290.CD-19-0608
doi: 10.1158/2159-8290.CD-19-0608
pmc: PMC7058499
mid: NIHMS1551454
doi:
Substances chimiques
Interferon Type I
0
STAT1 Transcription Factor
0
STAT1 protein, human
0
STAT2 Transcription Factor
0
STAT2 protein, human
0
Transcription Factors
0
Ubiquitins
0
UBA7 protein, human
EC 6.2.1.45
Ubiquitin-Activating Enzymes
EC 6.2.1.45
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
382-393Subventions
Organisme : NCI NIH HHS
ID : P30 CA023100
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA177305
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007250
Pays : United States
Organisme : NIBIB NIH HHS
ID : DP2 EB020400
Pays : United States
Informations de copyright
©2020 American Association for Cancer Research.
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