Tracking complex mixtures of chemicals in our changing environment.
Journal
Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511
Informations de publication
Date de publication:
24 01 2020
24 01 2020
Historique:
entrez:
25
1
2020
pubmed:
25
1
2020
medline:
22
4
2020
Statut:
ppublish
Résumé
Chemicals have improved our quality of life, but the resulting environmental pollution has the potential to cause detrimental effects on humans and the environment. People and biota are chronically exposed to thousands of chemicals from various environmental sources through multiple pathways. Environmental chemists and toxicologists have moved beyond detecting and quantifying single chemicals to characterizing complex mixtures of chemicals in indoor and outdoor environments and biological matrices. We highlight analytical and bioanalytical approaches to isolating, characterizing, and tracking groups of chemicals of concern in complex matrices. Techniques that combine chemical analysis and bioassays have the potential to facilitate the identification of mixtures of chemicals that pose a combined risk.
Identifiants
pubmed: 31974244
pii: 367/6476/388
doi: 10.1126/science.aay6636
pmc: PMC7153918
mid: NIHMS1568614
doi:
Substances chimiques
Complex Mixtures
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
388-392Subventions
Organisme : NIEHS NIH HHS
ID : R01 ES016099
Pays : United States
Informations de copyright
Copyright © 2020, American Association for the Advancement of Science.
Références
Environ Sci Technol. 2011 May 1;45(9):3835-47
pubmed: 21473617
Environ Sci Technol. 2011 Sep 15;45(18):7936-44
pubmed: 21842831
Science. 2010 Oct 22;330(6003):460-1
pubmed: 20966241
Anal Bioanal Chem. 2010 Jan;396(1):273-96
pubmed: 19924407
Science. 2013 Aug 16;341(6147):752-8
pubmed: 23950532
Chem Res Toxicol. 2012 Jul 16;25(7):1287-302
pubmed: 22519603
Environ Sci Technol. 2014 Feb 18;48(4):2097-8
pubmed: 24476540
Sci Total Environ. 2017 Dec 1;601-602:1849-1868
pubmed: 28629112
Environ Health Perspect. 2014 Aug;122(8):769-74
pubmed: 24659601
Nucleic Acids Res. 2019 Jan 8;47(D1):D1102-D1109
pubmed: 30371825
Environ Sci Process Impacts. 2018 Mar 1;20(3):493-504
pubmed: 29493668
Water Res. 2015 Apr 1;72:3-27
pubmed: 25267363
Crit Rev Toxicol. 2011 May;41(5):369-83
pubmed: 21309635
Environ Sci Technol. 2010 Aug 15;44(16):6024-35
pubmed: 20704196
Science. 2018 Jul 20;361(6399):224-226
pubmed: 30026211
Environ Int. 2016 Mar;88:269-280
pubmed: 26812473
Environ Sci Technol. 2016 Jun 7;50(11):5424-31
pubmed: 26804122
Environ Toxicol Chem. 2018 Sep;37(9):2273-2280
pubmed: 29846006
Sci Total Environ. 2016 Feb 15;544:1073-118
pubmed: 26779957
Water Res. 2017 Oct 15;123:734-750
pubmed: 28728110
Toxicol Sci. 2016 Aug;152(2):323-39
pubmed: 27208079
PLoS One. 2014 May 02;9(5):e96580
pubmed: 24794244
Environ Sci Technol. 2014 Mar 18;48(6):3327-35
pubmed: 24548134
Environ Sci Technol. 2013 Aug 6;47(15):8902-12
pubmed: 23763488
Curr Opin Pharmacol. 2014 Dec;19:105-11
pubmed: 25244397
Lancet. 2018 Feb 3;391(10119):462-512
pubmed: 29056410
Environ Sci Technol. 2019 Feb 19;53(4):1985-1993
pubmed: 30663877
Environ Sci Technol. 2017 Oct 17;51(20):11505-11512
pubmed: 28877430
Cancer Epidemiol Biomarkers Prev. 2005 Aug;14(8):1847-50
pubmed: 16103423
Environ Sci Technol. 2019 Mar 19;53(6):2950-2960
pubmed: 30834750
Environ Sci Technol. 2018 Oct 16;52(20):11875-11885
pubmed: 30216050
Environ Sci Technol. 2019 Jan 15;53(2):973-983
pubmed: 30548063
Environ Sci Technol. 2019 Aug 6;53(15):8585-8590
pubmed: 31329422
Drug Discov Today. 2013 Aug;18(15-16):716-23
pubmed: 23732176
Anal Bioanal Chem. 2015 Aug;407(21):6237-55
pubmed: 25976391
Environ Toxicol Chem. 2019 Jan;38(1):12-26
pubmed: 30570782