Sodium Bicarbonate Supplementation and Urinary TGF-
Aged
Aged, 80 and over
Biomarkers
/ urine
Creatinine
/ urine
Diabetes Mellitus, Type 1
/ complications
Diabetes Mellitus, Type 2
/ complications
Diabetic Nephropathies
/ diagnosis
Double-Blind Method
Female
Fibronectins
/ urine
Hepatitis A Virus Cellular Receptor 1
/ metabolism
Humans
Lipocalin-2
/ urine
Male
Middle Aged
Sodium Bicarbonate
/ adverse effects
Time Factors
Transforming Growth Factor beta1
/ urine
Treatment Outcome
Utah
Veterans
TGF-beta
acidosis
albumins
ammonium compounds
bicarbonate
carbon dioxide
chronic kidney disease
chronic renal insufficiency
creatinine
diabetes mellitus
diabetic nephropathies
fibronectins
hepatitis A virus cellular receptor 1
human FN1 protein
human HAVCR1 protein
human LCN2 protein
humans
kidney function tests
lipocalin
sodium bicarbonate
transforming growth factors
veterans
Journal
Clinical journal of the American Society of Nephrology : CJASN
ISSN: 1555-905X
Titre abrégé: Clin J Am Soc Nephrol
Pays: United States
ID NLM: 101271570
Informations de publication
Date de publication:
07 02 2020
07 02 2020
Historique:
received:
06
06
2019
accepted:
10
12
2019
pubmed:
25
1
2020
medline:
1
6
2021
entrez:
25
1
2020
Statut:
ppublish
Résumé
In early-phase studies of individuals with hypertensive CKD and normal serum total CO We conducted a randomized, double-blinded, placebo-controlled study in 74 United States veterans with type 1 or 2 diabetes mellitus, eGFR of 15-89 ml/min per 1.73 m Key baseline characteristics were age 72±8 years, eGFR of 51±18 ml/min per 1.73 m In nonacidotic diabetic kidney disease, sodium bicarbonate did not significantly reduce urinary TGF-
Sections du résumé
BACKGROUND AND OBJECTIVES
In early-phase studies of individuals with hypertensive CKD and normal serum total CO
DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS
We conducted a randomized, double-blinded, placebo-controlled study in 74 United States veterans with type 1 or 2 diabetes mellitus, eGFR of 15-89 ml/min per 1.73 m
RESULTS
Key baseline characteristics were age 72±8 years, eGFR of 51±18 ml/min per 1.73 m
CONCLUSIONS
In nonacidotic diabetic kidney disease, sodium bicarbonate did not significantly reduce urinary TGF-
Identifiants
pubmed: 31974286
pii: 01277230-202002000-00009
doi: 10.2215/CJN.06600619
pmc: PMC7015087
doi:
Substances chimiques
Biomarkers
0
Fibronectins
0
HAVCR1 protein, human
0
Hepatitis A Virus Cellular Receptor 1
0
LCN2 protein, human
0
Lipocalin-2
0
TGFB1 protein, human
0
Transforming Growth Factor beta1
0
Sodium Bicarbonate
8MDF5V39QO
Creatinine
AYI8EX34EU
Types de publication
Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
200-208Subventions
Organisme : CSRD VA
ID : I01 CX001695
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK091437
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK118219
Pays : United States
Informations de copyright
Copyright © 2020 by the American Society of Nephrology.
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