Lifetime cumulative exposure to rubber dust, fumes and N-nitrosamines and non-cancer mortality: a 49-year follow-up of UK rubber factory workers.
Adult
Cardiovascular Diseases
/ chemically induced
Chronic Disease
/ mortality
Dust
/ analysis
Environmental Monitoring
/ methods
Follow-Up Studies
Humans
Male
Middle Aged
Neoplasms
Nitrosamines
/ adverse effects
Occupational Diseases
/ chemically induced
Occupational Exposure
/ adverse effects
Respiratory Tract Diseases
/ chemically induced
Risk Factors
Rubber
/ adverse effects
Survival Analysis
United Kingdom
/ epidemiology
longitudinal studies
mortality studies
rubber
Journal
Occupational and environmental medicine
ISSN: 1470-7926
Titre abrégé: Occup Environ Med
Pays: England
ID NLM: 9422759
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
received:
18
10
2019
revised:
19
12
2019
accepted:
31
12
2019
pubmed:
25
1
2020
medline:
25
6
2020
entrez:
25
1
2020
Statut:
ppublish
Résumé
To examine associations between occupational exposures to rubber dust, rubber fumes and N-nitrosamines and non-cancer mortality. A cohort of 36 441 males aged 35+ years employed in British rubber factories was followed-up to 2015 (94% deceased). Competing risk survival analysis was used to assess risks of dying from non-cancer diseases (respiratory, urinary, cerebrovascular, circulatory and digestive diseases). Occupational exposures to rubber dust, rubber fumes, N-nitrosamines were derived based on a population-specific quantitative job-exposure matrix which in-turn was based on measurements in the EU-EXASRUB database. Exposure-response associations of increased risk with increasing exposure were found for N-nitrosomorpholine with mortality from circulatory diseases (subdistribution hazard ratio (SHR) 1.17; 95% CI 1.12 to 1.23), ischaemic heart disease (IHD) (SHR 1.19; 95% CI 1.13 to 1.26), cerebrovascular disease (SHR 1.19; 95% CI 1.07 to 1.32) and exposures to N-nitrosodimethylamine with respiratory disease mortality (SHR 1.41; 95% CI 1.30 to 1.53). Increased risks for mortality from circulatory disease, IHD and digestive diseases were found with higher levels of exposures to rubber dust, rubber fumes and N-nitrosamines sum, without an exposure-dependent manner. No associations were observed between rubber dust, rubber fumes and N-nitrosamines exposures with mortality from asthma, urinary disease, bronchitis, emphysema, liver disease and some digestive diseases. In a cohort of rubber factory workers with 49 years of follow-up, increased risk for mortality from circulatory, cerebrovascular, respiratory and digestive diseases were found to be associated with cumulative occupational exposures to specific agents.
Identifiants
pubmed: 31974293
pii: oemed-2019-106269
doi: 10.1136/oemed-2019-106269
doi:
Substances chimiques
Dust
0
Nitrosamines
0
Rubber
9006-04-6
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
316-323Informations de copyright
© Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.