Expression pattern of placenta specific 8 and keratin 20 in different types of gastrointestinal cancer.
gastrointestinal cancer
keratin 20
placenta specific 8
poorly differentiated
well differentiated
Journal
Molecular medicine reports
ISSN: 1791-3004
Titre abrégé: Mol Med Rep
Pays: Greece
ID NLM: 101475259
Informations de publication
Date de publication:
02 2020
02 2020
Historique:
received:
22
02
2019
accepted:
06
11
2019
entrez:
25
1
2020
pubmed:
25
1
2020
medline:
7
10
2020
Statut:
ppublish
Résumé
The aim of the present study was to investigate the expression of keratin 20 (KRT20) and placenta specific 8 (PLAC8) in gastrointestinal (GI) cancer with various differentiation phenotypes. The present study retrospectively investigated archived formalin‑fixed paraffin‑embedded tissue samples from 12 patients at different stages of GI cancer [four with gastric cancer, four with pancreatic cancer and four with colorectal cancer (CRC)]. The stages were pre‑determined, according to differentiation phenotypes, by a pathologist of the Department of Pathology at Sijhih Cathay General Hospital. KRT20 and PLAC8 expression levels were assessed using immunohistochemistry. The CRC cell lines SW620 and Caco‑2 were used to assess interactions between KRT20 and PLAC8 via reverse transcription‑quantitative PCR. PLAC8 and KRT20 expression was observed consistently only in the well‑differentiated CRC tissue samples. Low KRT20 expression levels were observed in the PLAC8 knockdown SW620 cells. In addition, there was a positive association between PLAC8 and KRT20 expression in the differentiated Caco‑2 cells. According to the results of the present study, the differentiation status of GI cancer influenced KRT20 expression, particularly in CRC, which may explain why patients with well‑differentiated CRC display better clinical outcomes. Therefore, the prognostic significance of KRT20 and PLAC8 may be particularly crucial for patients with CRC displaying a well‑differentiated phenotype.
Identifiants
pubmed: 31974611
doi: 10.3892/mmr.2019.10871
pmc: PMC6947936
doi:
Substances chimiques
Keratin-20
0
PLAC8 protein, human
0
Proteins
0
RNA, Messenger
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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