Clinical isolates of Trichophyton rubrum are completely inhibited by photochemical treatment with a γ-cyclodextrin formulation of curcuminoids.
conidia
dermatophytes
light
photo-inactivation
tinea
Journal
Mycoses
ISSN: 1439-0507
Titre abrégé: Mycoses
Pays: Germany
ID NLM: 8805008
Informations de publication
Date de publication:
Apr 2020
Apr 2020
Historique:
received:
17
09
2019
revised:
14
01
2020
accepted:
18
01
2020
pubmed:
25
1
2020
medline:
17
9
2020
entrez:
25
1
2020
Statut:
ppublish
Résumé
It was shown previously that dermatophytes can markedly be inhibited by a photochemical treatment with curcumin. This kind of photo-inactivation needs to be improved, however, because curcumin is poorly water-soluble. Therefore, a new water-soluble γ-cyclodextrin formulation of curcuminoids was tested for its photochemical inactivation of Trichophyton (T.) rubrum. Conidia were harvested from 6 typical strains of T rubrum and used to inoculate wells of microtiter plates. These wells were also filled with a γ-cyclodextrin curcuminoid formulation with 0.1% DMSO and Sabouraud broth. The assays were then irradiated with visible light (wavelength 420 nm, 45 J/cm Growth of all 6 T rubrum strains was completely inhibited by the photochemical treatment with the γ-cyclodextrin formulation of curcuminoids. The same curcuminoid formulation applied without irradiation had only a minor inhibitory effect. Photo-inactivation of dermatophytes with a γ-cyclodextrin formulation of curcuminoids plus visible light is a very promising procedure with potential for a new treatment of patients with superficial tinea.
Substances chimiques
Antifungal Agents
0
Diarylheptanoids
0
Oxidants, Photochemical
0
gamma-Cyclodextrins
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
369-375Informations de copyright
© 2020 The Authors. Mycoses published by Blackwell Verlag GmbH.
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