Sirolimus for the Treatment of Airway Obstruction due to Indolent T-Lymphoblastic Proliferation.
Journal
Case reports in immunology
ISSN: 2090-6609
Titre abrégé: Case Reports Immunol
Pays: Egypt
ID NLM: 101622188
Informations de publication
Date de publication:
2019
2019
Historique:
received:
27
05
2019
revised:
01
10
2019
accepted:
17
10
2019
entrez:
25
1
2020
pubmed:
25
1
2020
medline:
25
1
2020
Statut:
epublish
Résumé
Indolent T-lymphoblastic proliferation (iT-LBP) is a rare nonmalignant entity that presents as a proliferation of T-lymphoblasts. We report a first such case with a recurrent laryngeal obstruction presentation that was successfully controlled with Sirolimus. This is the case of a 29-year-old female who presented with a recurrent significant lymphoid hyperplasia in the adenoid and tongue base region as well as a right cervical lymph node. After repeated adenoidectomies and tonsillectomies, and based on pathological and clinical findings she was diagnosed with iT-LBP. Trials of radiotherapy and immunotherapy with cyclosporine and rituximab all failed to control the progression of the disease. Sirolimus was finally able to restrict the growth and improve her symptoms. While It-LBP does not usually require treatment, it is important to report cases in which treatment was crucial for the survival of the patient, and the effective role of Sirolimus in doing so, without any major adverse effects.
Identifiants
pubmed: 31976096
doi: 10.1155/2019/1724083
pmc: PMC6959153
doi:
Types de publication
Case Reports
Langues
eng
Pagination
1724083Informations de copyright
Copyright © 2019 Eric Moughames et al.
Déclaration de conflit d'intérêts
The authors declare no potential conflicts of interest.
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