Tetramethylpyrazine: A promising drug for the treatment of pulmonary hypertension.

Animals Cell Proliferation Disease Models, Animal Humans Hypertension, Pulmonary / drug therapy Monocrotaline Myocytes, Smooth Muscle Pharmaceutical Preparations Pulmonary Artery Pyrazines Rats Rats, Sprague-Dawley

Journal

British journal of pharmacology
ISSN: 1476-5381
Titre abrégé: Br J Pharmacol
Pays: England
ID NLM: 7502536

Informations de publication

Date de publication:
06 2020
Historique:
received: 16 08 2018
revised: 28 11 2019
accepted: 07 01 2020
pubmed: 25 1 2020
medline: 22 6 2021
entrez: 25 1 2020
Statut: ppublish

Résumé

Tetramethylpyrazine (TMP) was originally isolated from the traditional Chinese herb ligusticum and the fermented Japanese food natto and has since been synthesized. TMP has a long history of beneficial effects in the treatment of many cardiovascular diseases. Here we have evaluated the therapeutic effects of TMP on pulmonary hypertension (PH) in animal models and in patients with pulmonary arterial hypertension (PAH) or chronic thromboembolic pulmonary hypertension (CTEPH). Three well-defined models of PH -chronic hypoxia (10% O TMP (100 mg·kg Our results suggest that TMP is a novel and inexpensive medication for treatment of PH. Clinical trial is registered with www.chictr.org.cn (ChiCTR-IPR-14005379).

Sections du résumé

BACKGROUND AND PURPOSE
Tetramethylpyrazine (TMP) was originally isolated from the traditional Chinese herb ligusticum and the fermented Japanese food natto and has since been synthesized. TMP has a long history of beneficial effects in the treatment of many cardiovascular diseases. Here we have evaluated the therapeutic effects of TMP on pulmonary hypertension (PH) in animal models and in patients with pulmonary arterial hypertension (PAH) or chronic thromboembolic pulmonary hypertension (CTEPH).
EXPERIMENTAL APPROACH
Three well-defined models of PH -chronic hypoxia (10% O
KEY RESULTS
TMP (100 mg·kg
CONCLUSION AND IMPLICATIONS
Our results suggest that TMP is a novel and inexpensive medication for treatment of PH. Clinical trial is registered with www.chictr.org.cn (ChiCTR-IPR-14005379).

Identifiants

DOI: 10.1111/bph.15000 PMID: 31976548 PMC: PMC7236078
pubmed: 31976548
doi: 10.1111/bph.15000
pmc: PMC7236078
doi:

Substances chimiques

Pharmaceutical Preparations 0
Pyrazines 0
Monocrotaline 73077K8HYV
tetramethylpyrazine V80F4IA5XG

Banques de données

ChiCTR
['ChiCTR‐IPR‐14005379']

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2743-2764

Subventions

Organisme : National Key R&D Project of China
ID : 2016YFC0903700
Organisme : the National Natural Science Foundation of China
ID : 81770043
Organisme : the National Natural Science Foundation of China
ID : 81520108001
Organisme : the Guangzhou Scientific Research Program
ID : 201804020090
Organisme : and the State Key Laboratory of Respiratory Disease
ID : SKLRD-QN-201704
Organisme : the National Natural Science Foundation of China
ID : 81800057
Organisme : the Guangdong Department of Science and Technology
ID : 2017A020215114
Organisme : NHLBI NIH HHS
ID : R35 HL135807
Pays : United States
Organisme : the Guangzhou Department of Education
ID : 1201630095
Organisme : NHLBI NIH HHS
ID : R01 HL136603
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL141387
Pays : United States
Organisme : the Chang Jiang Scholars and Innovative Research Team in University
ID : IRT0961
Organisme : NHLBI NIH HHS
ID : P01 HL134610
Pays : United States
Organisme : the Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme (2014, for WL)
Organisme : and the State Key Laboratory of Respiratory Disease
ID : SKLRD-OP-201808
Organisme : the Guangdong Department of Science and Technology
ID : 2016A030313606
Organisme : the National Natural Science Foundation of China
ID : 81630004
Organisme : the Guangdong Department of Science and Technology
ID : 2016A030311020
Organisme : and the State Key Laboratory of Respiratory Disease
ID : SKLRD-QN-201919
Organisme : the Guangzhou Department of Education
ID : 1201620007
Organisme : the Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program
ID : 2017BT01S155
Organisme : 973 Key Scheme of China
ID : 2015CB553406
Organisme : NHLBI NIH HHS
ID : U01 HL125208
Pays : United States
Organisme : National Key R&D Project of China
ID : 2016YFC1304102
Organisme : the National Natural Science Foundation of China
ID : 81800061

Informations de copyright

© 2020 The British Pharmacological Society.

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Auteurs

Yuqin Chen (Y)

State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Wenju Lu (W)

State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
ORCID: 0000-0002-5035-9287

Kai Yang (K)

State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
ORCID: 0000-0003-3044-2240

Xin Duan (X)

State Key Laboratory of Cardiovascular Disease, Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Mengxi Li (M)

State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Xiuqing Chen (X)

State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Jie Zhang (J)

State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Meidan Kuang (M)

State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Shiyun Liu (S)

State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Xiongting Wu (X)

State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Guofa Zou (G)

State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Chunli Liu (C)

State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Cheng Hong (C)

State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Wenjun He (W)

State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Jing Liao (J)

State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Chi Hou (C)

Department of Neurology, Guangzhou Women and Children's Medical Center, Guangzhou, China.

Zhe Zhang (Z)

State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Qiuyu Zheng (Q)

State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Jiyuan Chen (J)

State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Nuofu Zhang (N)

State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Haiyang Tang (H)

State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Departments of Medicine and Physiology, The University of Arizona, Tucson, Arizona.

Rebecca R Vanderpool (RR)

Departments of Medicine and Physiology, The University of Arizona, Tucson, Arizona.

Ankit A Desai (AA)

Departments of Medicine and Physiology, The University of Arizona, Tucson, Arizona.

Franz Rischard (F)

Departments of Medicine and Physiology, The University of Arizona, Tucson, Arizona.

Stephen M Black (SM)

Departments of Medicine and Physiology, The University of Arizona, Tucson, Arizona.

Joe G N Garcia (JGN)

Departments of Medicine and Physiology, The University of Arizona, Tucson, Arizona.

Ayako Makino (A)

Department of Medicine, University of California, San Diego, La Jolla, California, USA.

Jason X-J Yuan (JX)

Department of Medicine, University of California, San Diego, La Jolla, California, USA.

Nanshan Zhong (N)

State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Jian Wang (J)

State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Division of Pulmonary and Critical Care Medicine, The People's Hospital of Inner Mongolia, Huhhot, China.
Department of Medicine, University of California, San Diego, La Jolla, California, USA.
ORCID: 0000-0002-1278-256X

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Tetramethylpyrazine: A promising drug for the...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Processus de croissance cellulaire › Prolifération cellulaire › Tetramethylpyrazine: A promising drug for the...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Tetramethylpyrazine: A promising drug for the...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Tetramethylpyrazine: A promising drug for the...
questionsmedicales.fr › Maladies cardiovasculaires › Maladies vasculaires › Hypertension artérielle › Hypertension pulmonaire › Tetramethylpyrazine: A promising drug for the...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Alcaloïdes de type pyrrolizidine › Monocrotaline › Tetramethylpyrazine: A promising drug for the...
questionsmedicales.fr › Cellules › Cellules musculaires › Myocytes du muscle lisse › Tetramethylpyrazine: A promising drug for the...
questionsmedicales.fr › Préparations pharmaceutiques › Tetramethylpyrazine: A promising drug for the...
questionsmedicales.fr › Système cardiovasculaire › Vaisseaux sanguins › Artères › Artère pulmonaire › Tetramethylpyrazine: A promising drug for the...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyrazines › Tetramethylpyrazine: A promising drug for the...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Tetramethylpyrazine: A promising drug for the...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rat Sprague-Dawley › Tetramethylpyrazine: A promising drug for the...