Prognostic value of systemic inflammatory response syndrome and serum concentrations of acute phase proteins, cholesterol, and total thyroxine in cats with panleukopenia.
diarrhea and vomiting
feline infection
infectious diseases
parvovirus
Journal
Journal of veterinary internal medicine
ISSN: 1939-1676
Titre abrégé: J Vet Intern Med
Pays: United States
ID NLM: 8708660
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
received:
29
03
2019
accepted:
10
01
2020
pubmed:
25
1
2020
medline:
15
12
2020
entrez:
25
1
2020
Statut:
ppublish
Résumé
Feline parvovirus (FPV) is a common and potentially lethal infectious agent in cats. To assess the prognostic value of age, neuter status, serum concentrations of serum amyloid A (SAA), haptoglobin, cholesterol and total thyroxine (tT4), and the presence of systemic inflammatory response syndrome (SIRS) in cats with panleukopenia. Client-owned cats with FPV infection diagnosed by a positive fecal ELISA test, positive PCR on feces or blood or both. Retrospective cohort study. The electronic medical database was searched for cats with FPV infection presented between January 2010 and January 2018. Cats were divided into survivors and nonsurvivors according to their survival status 28 days after hospital admission. The prognostic importance of each variable was investigated univariately and by multivariable Cox's proportional-hazards regression. Finally, receiver operator characteristic (ROC) curve analysis was used to identify the best cutoff value for discriminating survivors from nonsurvivors for the statistically significant prognostic predictors identified by multivariable analysis. Seventy cats were enrolled in the study. Multivariable analysis determined that only serum tT4 concentration at hospital admission was significantly (P = .01) associated with survival. A cutoff value of 0.82 μg/dL was identified by ROC curve analysis for serum tT4 concentration in discriminating survivors from nonsurvivors. Sensitivity at this cutoff was 73.9% and specificity was 82.9% (area under the curve, 0.783; 95% confidence interval, 0.668-0.873; P < .0001). Serum tT4 concentration at hospital admission has prognostic value in cats with FPV infection.
Sections du résumé
BACKGROUND
BACKGROUND
Feline parvovirus (FPV) is a common and potentially lethal infectious agent in cats.
OBJECTIVE
OBJECTIVE
To assess the prognostic value of age, neuter status, serum concentrations of serum amyloid A (SAA), haptoglobin, cholesterol and total thyroxine (tT4), and the presence of systemic inflammatory response syndrome (SIRS) in cats with panleukopenia.
ANIMALS
METHODS
Client-owned cats with FPV infection diagnosed by a positive fecal ELISA test, positive PCR on feces or blood or both.
METHODS
METHODS
Retrospective cohort study. The electronic medical database was searched for cats with FPV infection presented between January 2010 and January 2018. Cats were divided into survivors and nonsurvivors according to their survival status 28 days after hospital admission. The prognostic importance of each variable was investigated univariately and by multivariable Cox's proportional-hazards regression. Finally, receiver operator characteristic (ROC) curve analysis was used to identify the best cutoff value for discriminating survivors from nonsurvivors for the statistically significant prognostic predictors identified by multivariable analysis.
RESULTS
RESULTS
Seventy cats were enrolled in the study. Multivariable analysis determined that only serum tT4 concentration at hospital admission was significantly (P = .01) associated with survival. A cutoff value of 0.82 μg/dL was identified by ROC curve analysis for serum tT4 concentration in discriminating survivors from nonsurvivors. Sensitivity at this cutoff was 73.9% and specificity was 82.9% (area under the curve, 0.783; 95% confidence interval, 0.668-0.873; P < .0001).
CONCLUSION AND CLINICAL RELEVANCE
CONCLUSIONS
Serum tT4 concentration at hospital admission has prognostic value in cats with FPV infection.
Identifiants
pubmed: 31977127
doi: 10.1111/jvim.15704
pmc: PMC7096634
doi:
Substances chimiques
Acute-Phase Proteins
0
Cholesterol
97C5T2UQ7J
Thyroxine
Q51BO43MG4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
719-724Informations de copyright
© 2020 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.
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