Local Injection of Botulinum Toxin Type A to Prevent Postoperative Scar.
Journal
The Journal of craniofacial surgery
ISSN: 1536-3732
Titre abrégé: J Craniofac Surg
Pays: United States
ID NLM: 9010410
Informations de publication
Date de publication:
Historique:
pubmed:
25
1
2020
medline:
11
7
2020
entrez:
25
1
2020
Statut:
ppublish
Résumé
Physical scars, especially those in the head and neck area, can cause emotional and psychological distress. Recent studies, have suggested that botulinum toxin type A (BTX-A), also known as Botox, may improve surgical scars by speeding up the wound healing process. Injection of BTX-A is generally considered a less invasive approach. The purpose of this meta-analysis was to assess the efficacy and safety of BTX-A in the prevention of postoperative scars compared to placebo or no treatment. Following databases were searched from inception to March 2019: Cochrane Library, EMBASE, Web of Science, PubMed, and Open grey. Five trials registers were searched for potentially related trials. The authors also searched reference lists of relevant articles and contacted the investigators to identify additional published and unpublished studies. Two authors independently evaluated all potential studies that met the selection criteria. Two authors independently extracted and analyzed the data. Analysis was conducted on 267 patients who were enrolled in trials and randomly assigned to receive local injection of BTX-A (184 patients) and placebo (182 patients). Improved Vancouver scar scale scores were noted among patients treated with BTX-A injections compared with the control group (P = .000). The visual analogue scale scores revealed a significant improvement in appearance for the BTX-A-treated scars (P = .000). In addition, lower increase in width of the wound was observed in the experimental group compared to the control group (P = .000). This systematic review provided preliminary evidence that supports the efficacy and safety of BTX-A for the prevention of postoperative scar.
Sections du résumé
BACKGROUND
BACKGROUND
Physical scars, especially those in the head and neck area, can cause emotional and psychological distress. Recent studies, have suggested that botulinum toxin type A (BTX-A), also known as Botox, may improve surgical scars by speeding up the wound healing process. Injection of BTX-A is generally considered a less invasive approach.
OBJECTIVES
OBJECTIVE
The purpose of this meta-analysis was to assess the efficacy and safety of BTX-A in the prevention of postoperative scars compared to placebo or no treatment.
MATERIALS AND METHODS
METHODS
Following databases were searched from inception to March 2019: Cochrane Library, EMBASE, Web of Science, PubMed, and Open grey. Five trials registers were searched for potentially related trials. The authors also searched reference lists of relevant articles and contacted the investigators to identify additional published and unpublished studies.
DATA COLLECTION AND ANALYSIS
METHODS
Two authors independently evaluated all potential studies that met the selection criteria. Two authors independently extracted and analyzed the data.
RESULTS
RESULTS
Analysis was conducted on 267 patients who were enrolled in trials and randomly assigned to receive local injection of BTX-A (184 patients) and placebo (182 patients). Improved Vancouver scar scale scores were noted among patients treated with BTX-A injections compared with the control group (P = .000). The visual analogue scale scores revealed a significant improvement in appearance for the BTX-A-treated scars (P = .000). In addition, lower increase in width of the wound was observed in the experimental group compared to the control group (P = .000).
RECOMMENDATION
CONCLUSIONS
This systematic review provided preliminary evidence that supports the efficacy and safety of BTX-A for the prevention of postoperative scar.
Identifiants
pubmed: 31977704
doi: 10.1097/SCS.0000000000006144
pii: 00001665-202004000-00031
doi:
Substances chimiques
Botulinum Toxins, Type A
EC 3.4.24.69
Types de publication
Journal Article
Meta-Analysis
Systematic Review
Langues
eng
Pagination
440-443Commentaires et corrections
Type : CommentIn
Références
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