Reduced gray matter volume and cortical thickness associated with traffic-related air pollution in a longitudinally studied pediatric cohort.
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2020
2020
Historique:
received:
02
10
2019
accepted:
07
01
2020
entrez:
25
1
2020
pubmed:
25
1
2020
medline:
15
4
2020
Statut:
epublish
Résumé
Early life exposure to air pollution poses a significant risk to brain development from direct exposure to toxicants or via indirect mechanisms involving the circulatory, pulmonary or gastrointestinal systems. In children, exposure to traffic related air pollution has been associated with adverse effects on cognitive, behavioral and psychomotor development. We aimed to determine whether childhood exposure to traffic related air pollution is associated with regional differences in brain volume and cortical thickness among children enrolled in a longitudinal cohort study of traffic related air pollution and child health. We used magnetic resonance imaging to obtain anatomical brain images from a nested subset of 12 year old participants characterized with either high or low levels of traffic related air pollution exposure during their first year of life. We employed voxel-based morphometry to examine group differences in regional brain volume, and with separate analyses, changes in cortical thickness. Smaller regional gray matter volumes were determined in the left pre- and post-central gyri, the cerebellum, and inferior parietal lobe of participants in the high traffic related air pollution exposure group relative to participants with low exposure. Reduced cortical thickness was observed in participants with high exposure relative to those with low exposure, primarily in sensorimotor regions of the brain including the pre- and post-central gyri and the paracentral lobule, but also within the frontal and limbic regions. These results suggest that significant childhood exposure to traffic related air pollution is associated with structural alterations in brain.
Identifiants
pubmed: 31978108
doi: 10.1371/journal.pone.0228092
pii: PONE-D-19-27642
pmc: PMC6980590
doi:
Substances chimiques
Carbon
7440-44-0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0228092Subventions
Organisme : NIEHS NIH HHS
ID : R01 ES026446
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES027224
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES019890
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM063483
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001425
Pays : United States
Organisme : NIEHS NIH HHS
ID : T32 ES010957
Pays : United States
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Neurotoxicology. 2018 Jul;67:1-26
pubmed: 29634994
Hum Brain Mapp. 1998;6(5-6):348-57
pubmed: 9788071
J Pediatr. 2006 Oct;149(4):505-11
pubmed: 17011322
Ann Epidemiol. 2019 Feb;30:37-43
pubmed: 30563729
Nat Rev Neurosci. 2009 Oct;10(10):724-35
pubmed: 19763105
Environ Res. 2019 Jun;173:199-206
pubmed: 30925441
PLoS Med. 2015 Mar 03;12(3):e1001792
pubmed: 25734425
Hum Brain Mapp. 2009 Jul;30(7):2252-66
pubmed: 19107748
Sci Total Environ. 2011 Jun 1;409(13):2642-51
pubmed: 21496880
Environ Sci Pollut Res Int. 2014 Mar;21(5):3351-62
pubmed: 24234816
Inhal Toxicol. 2013 Dec;25(14):802-12
pubmed: 24304307
Arch Gen Psychiatry. 2006 May;63(5):540-9
pubmed: 16651511
Cereb Cortex. 2015 Aug;25(8):2204-12
pubmed: 24591525
Psychol Rep. 1990 Apr;66(2):659-66
pubmed: 2349356
Brain Imaging Behav. 2018 Jun;12(3):882-890
pubmed: 28699075
Early Hum Dev. 2013 Jun;89(6):371-80
pubmed: 23273486
Biol Psychiatry. 2018 Aug 15;84(4):295-303
pubmed: 29530279
PLoS Med. 2008 May 27;5(5):e112
pubmed: 18507499
Toxicol Pathol. 2004 Nov-Dec;32(6):650-8
pubmed: 15513908
J Alzheimers Dis. 2012;28(1):93-107
pubmed: 21955814
Neuroimage. 2009 Jan 1;44(1):83-98
pubmed: 18501637
Cereb Cortex. 2009 Nov;19(11):2728-35
pubmed: 19299253
J Toxicol. 2012;2012:782462
pubmed: 22523490
Brain. 1999 Apr;122 ( Pt 4):593-624
pubmed: 10219775
Neuroimage. 2000 Jun;11(6 Pt 1):805-21
pubmed: 10860804
Biol Psychiatry. 2007 Jun 15;61(12):1361-9
pubmed: 16950217
Cereb Cortex. 2016 Jan;26(1):257-267
pubmed: 25246511
Schizophr Bull. 2014 Mar;40(2):410-9
pubmed: 23419977
Brain Res. 1994 Aug 8;653(1-2):173-82
pubmed: 7982051
Curr Opin Neurobiol. 1993 Dec;3(6):958-65
pubmed: 8124080
Environ Health Perspect. 2000 Jun;108 Suppl 3:375-81
pubmed: 10852831
Brain Cogn. 2008 Nov;68(2):117-27
pubmed: 18550243
Environ Res. 2016 Nov;151:763-776
pubmed: 27609410
Prog Neuropsychopharmacol Biol Psychiatry. 2018 Jul 13;85:23-32
pubmed: 29627508
Proc Natl Acad Sci U S A. 2011 Aug 9;108(32):13281-6
pubmed: 21788513
J Anxiety Disord. 2009 Dec;23(8):1072-9
pubmed: 19674869
Environ Health Perspect. 2015 Aug;123(8):834-40
pubmed: 25816123
Atmos Environ (1994). 2006;40(S2):378-395
pubmed: 21720518
Hum Brain Mapp. 2011 Jul;32(7):1109-24
pubmed: 20665722
J Allergy Clin Immunol. 2005 Aug;116(2):279-84
pubmed: 16083780
J Neuropsychiatry Clin Neurosci. 2004 Summer;16(3):367-78
pubmed: 15377747
Prog Brain Res. 1990;85:185-222
pubmed: 2094894
Environ Health Perspect. 2017 Mar;125(3):342-348
pubmed: 27517877
Child Dev. 2000 Jan-Feb;71(1):44-56
pubmed: 10836557
Trends Neurosci. 2009 Sep;32(9):506-16
pubmed: 19716187
J Anat. 2010 Oct;217(4):276-88
pubmed: 20979582
Environ Health Perspect. 2008 May;116(5):674-9
pubmed: 18470301
Psychiatry Res. 2014 Dec 30;224(3):242-5
pubmed: 25443178
Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19649-54
pubmed: 18024590
Proc Natl Acad Sci U S A. 2004 May 25;101(21):8174-9
pubmed: 15148381
Lancet. 1995 Jan 21;345(8943):176-8
pubmed: 7741860
Front Neuroanat. 2009 Aug 20;3:16
pubmed: 19738926
Neural Regen Res. 2016 Jan;11(1):119-25
pubmed: 26981099
Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):13135-40
pubmed: 20624964
Neuroimage. 2000 Dec;12(6):676-87
pubmed: 11112399
Science. 1988 Jul 8;241(4862):170-6
pubmed: 3291116
Brain. 1998 Apr;121 ( Pt 4):561-79
pubmed: 9577385
Neurotoxicology. 2017 Mar;59:140-154
pubmed: 26721665
Nat Neurosci. 1999 Oct;2(10):861-3
pubmed: 10491603
Toxicol Pathol. 2003 Sep-Oct;31(5):524-38
pubmed: 14692621
Cereb Cortex. 2013 Nov;23(11):2724-33
pubmed: 22923087
Cerebellum. 2007;6(3):254-67
pubmed: 17786822
Hum Brain Mapp. 2000 Sep;11(1):12-32
pubmed: 10997850
Neurotoxicology. 2017 Mar;59:133-139
pubmed: 26610921
Neuroimage. 2001 Jul;14(1 Pt 1):21-36
pubmed: 11525331
Environ Res. 2016 May;147:383-98
pubmed: 26945620
PLoS One. 2012;7(5):e37252
pubmed: 22615955
Brain Res. 1995 Apr 24;678(1-2):233-43
pubmed: 7542541
Cereb Cortex. 2007 Nov;17(11):2703-12
pubmed: 17264251
Arch Pathol Lab Med. 1980 Dec;104(12):635-9
pubmed: 6893659
Proc Natl Acad Sci U S A. 2000 Sep 26;97(20):11050-5
pubmed: 10984517
Eur Psychiatry. 2008 Jun;23(4):289-99
pubmed: 17765485
Environ Res. 2019 Aug;175:71-78
pubmed: 31103795
Hum Brain Mapp. 2018 Aug;39(8):3308-3325
pubmed: 29717540
J Neurosci. 1996 Dec 1;16(23):7688-98
pubmed: 8922425
Hum Brain Mapp. 2018 Jun;39(6):2442-2454
pubmed: 29473262
Trends Neurosci. 2000 Aug;23(8):352-9
pubmed: 10906798
J Neurosci. 2008 Nov 19;28(47):12176-82
pubmed: 19020011
Neuron. 2014 Aug 6;83(3):518-32
pubmed: 25102558
Lancet. 2017 Feb 18;389(10070):718-726
pubmed: 28063597
J Atten Disord. 2013 Nov;17(8):641-54
pubmed: 22392552
Arch Neurol. 1970 Jul;23(1):41-58
pubmed: 4987142
BMJ. 2015 Mar 24;350:h1111
pubmed: 25810495
Basic Clin Pharmacol Toxicol. 2019 Aug;125 Suppl 3:81-88
pubmed: 30884144
JAMA Psychiatry. 2013 Jan;70(1):71-7
pubmed: 23404082
Part Fibre Toxicol. 2006 Sep 08;3:13
pubmed: 16961926
Endocrinology. 2015 Oct;156(10):3473-82
pubmed: 26241071
Schizophr Res. 2004 Jan 1;66(1):83-5
pubmed: 14693358
Biomed Res Int. 2014;2014:736385
pubmed: 24524086
Environ Health Perspect. 2007 Feb;115(2):278-84
pubmed: 17384778
PLoS One. 2013 May 29;8(5):e64128
pubmed: 23734187
Neuroimage. 2007 Oct 15;38(1):95-113
pubmed: 17761438
Cereb Cortex. 2017 Feb 1;27(2):1472-1481
pubmed: 28365755
Environ Health Perspect. 2010 Sep;118(9):1326-31
pubmed: 20406721
Prog Brain Res. 1994;102:227-43
pubmed: 7800815
J Neuroimaging. 2011 Apr;21(2):e134-47
pubmed: 20412393
Neuroimage. 2001 Feb;13(2):375-80
pubmed: 11162277
J Toxicol Environ Health A. 2002 Oct 25;65(20):1531-43
pubmed: 12396867
Neuroimage. 2009 Nov 1;48(2):371-80
pubmed: 19559801
Int J Hyg Environ Health. 2017 Aug;220(6):1074-1080
pubmed: 28705430
Cerebellum. 2005;4(4):290-4
pubmed: 16321885
Environ Health Perspect. 1995 Sep;103 Suppl 6:73-6
pubmed: 8549496
J Child Psychol Psychiatry. 2006 Oct;47(10):1003-12
pubmed: 17073979
AIMS Environ Sci. 2015;2(2):353-373
pubmed: 27099868
Emotion. 2007 May;7(2):336-53
pubmed: 17516812
Environ Health Perspect. 2006 Aug;114(8):1287-92
pubmed: 16882541
Environ Health Perspect. 2013 Jun;121(6):731-6
pubmed: 23694812
Neuroreport. 2011 Feb 16;22(3):101-5
pubmed: 21233781
J Anxiety Disord. 2015 May;32:81-8
pubmed: 25890287
Inhal Toxicol. 2004 Jun;16(6-7):437-45
pubmed: 15204759
Toxicol Pathol. 2002 May-Jun;30(3):373-89
pubmed: 12051555
Sci Total Environ. 2008 Oct 1;404(1):139-47
pubmed: 18625514
Neuroscience. 2014 Sep 26;277:577-83
pubmed: 25086308
Neuroimage. 2012 Jul 16;61(4):805-11
pubmed: 22465459
Neurotoxicology. 2016 Sep;56:235-253
pubmed: 27328897
Toxicol Pathol. 2008 Feb;36(2):289-310
pubmed: 18349428
Neuroimage. 2004;23 Suppl 1:S2-18
pubmed: 15501091
Neuroimage. 2013 Jan 15;65:336-48
pubmed: 23041529