The value of avian gross pathology in identifying endocrine disrupting properties.
Avian reproduction test
Endocrine disruption
Gross pathology
Necropsy
Regulatory toxicology
Journal
Regulatory toxicology and pharmacology : RTP
ISSN: 1096-0295
Titre abrégé: Regul Toxicol Pharmacol
Pays: Netherlands
ID NLM: 8214983
Informations de publication
Date de publication:
Apr 2020
Apr 2020
Historique:
received:
26
08
2019
revised:
20
12
2019
accepted:
10
01
2020
pubmed:
25
1
2020
medline:
29
12
2020
entrez:
25
1
2020
Statut:
ppublish
Résumé
The European Chemical Agency and European Food Safety Authority recommend that gross pathology findings, from avian reproduction studies, be used to support assessment of potential endocrine disrupting properties of active pesticidal and biocidal substances. In open literature, little information is available on the utility of gross pathology data for informing endocrine evaluations. Here the gross pathology data from historical control groups of 51 northern bobwhite and 51 mallard reproduction tests is analyzed to evaluate the utility of such information. Incidence of gross morphology findings in untreated birds may aid the interpretation of some gross abnormalities, potentially indicative of an endocrine interaction (e.g. reproductive condition). Statistical analysis of the historical control data indicates that gross pathology is not likely to be useful for detecting endocrine effects as abnormalities with relatively high increases in prevalence (more than 20-30%, depending on prevalence in controls) are reliably interpreted as a treatment response. Gross pathology changes are only indicative and not diagnostic of endocrine interactions making it difficult to distinguish gross pathology abnormalities, due to endocrine-mediated effects, from systemic toxicity. This work demonstrates the utility of using historical control analyses to establish the value and properties of selected endpoints for regulatory applications.
Identifiants
pubmed: 31978447
pii: S0273-2300(20)30003-9
doi: 10.1016/j.yrtph.2020.104577
pii:
doi:
Substances chimiques
Endocrine Disruptors
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
104577Informations de copyright
Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Data utilized for evaluation of avian gross pathological findings was obtained from the Eurofins Agroscience Services historical control database. Funding for the statistical analysis of the historical control data and preparation of this publication was funded by Corteva Agriscience.