Synthesis of cationic quaternized pullulan derivatives for miRNA delivery.

Cations Epoxy Compounds / chemistry Gene Transfer Techniques Glucans / chemical synthesis Human Umbilical Vein Endothelial Cells / metabolism Humans MicroRNAs / administration & dosage Quaternary Ammonium Compounds / chemistry Static Electricity
Cationic derivatives Gene therapy Polyplexes Pullulan microRNA

Journal

International journal of pharmaceutics
ISSN: 1873-3476
Titre abrégé: Int J Pharm
Pays: Netherlands
ID NLM: 7804127

Informations de publication

Date de publication:
15 Mar 2020
Historique:
received: 08 11 2019
revised: 05 01 2020
accepted: 11 01 2020
pubmed: 25 1 2020
medline: 26 11 2020
entrez: 25 1 2020
Statut: ppublish

Résumé

Pullulan is a natural polysaccharide of potential interest for biomedical applications due to its non-toxic, non-immunogenic and biodegradable properties. The aim of this work was to synthesize cationic pullulan derivatives able to form complexes with microRNAs (miRNAs) driven by electrostatic interaction (polyplexes). Quaternized ammonium groups were linked to pullulan backbone by adding the reactive glycidyltrimethylammonium chloride (GTMAC). The presence of these cationic groups within the pullulan was confirmed by elemental analysis, Fourier-transform infrared spectroscopy (FTIR) and proton nuclear magnetic resonance (

Identifiants

DOI: 10.1016/j.ijpharm.2020.119041 PMID: 31978463
pubmed: 31978463
pii: S0378-5173(20)30023-5
doi: 10.1016/j.ijpharm.2020.119041
pii:
doi:

Substances chimiques

Cations 0
Epoxy Compounds 0
Glucans 0
MicroRNAs 0
Quaternary Ammonium Compounds 0
glycidyl trimethylammonium 3033-77-0
pullulan 8ZQ0AYU1TT

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

119041

Informations de copyright

Copyright © 2020 Elsevier B.V. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Fernanda C Moraes (FC)

INSERM, U1148, Laboratory for Vascular Translational Science, X. Bichat Hospital, 46 rue Henri Huchard, 75018, Paris, France; Université de Paris, Université Sorbonne Paris Nord, Paris, France. Electronic address: fernanda.moraes@inserm.fr.

Joana C Antunes (JC)

Universidade do Minho, 2C2T, Campus de Azurém, 4800-058 Guimarães, Portugal. Electronic address: joana.antunes@2c2t.uminho.pt.

Laura Marcela Forero Ramirez (LM)

INSERM, U1148, Laboratory for Vascular Translational Science, X. Bichat Hospital, 46 rue Henri Huchard, 75018, Paris, France; Université de Paris, Université Sorbonne Paris Nord, Paris, France. Electronic address: lmforeror@gmail.com.

Paola Aprile (P)

INSERM, U1148, Laboratory for Vascular Translational Science, X. Bichat Hospital, 46 rue Henri Huchard, 75018, Paris, France; Université de Paris, Université Sorbonne Paris Nord, Paris, France. Electronic address: paola.aprile@inserm.fr.

Gregory Franck (G)

INSERM, U1148, Laboratory for Vascular Translational Science, X. Bichat Hospital, 46 rue Henri Huchard, 75018, Paris, France; Université de Paris, Université Sorbonne Paris Nord, Paris, France. Electronic address: gregory.franck@inserm.fr.

Cédric Chauvierre (C)

INSERM, U1148, Laboratory for Vascular Translational Science, X. Bichat Hospital, 46 rue Henri Huchard, 75018, Paris, France; Université de Paris, Université Sorbonne Paris Nord, Paris, France. Electronic address: cedric.chauvierre@inserm.fr.

Frédéric Chaubet (F)

INSERM, U1148, Laboratory for Vascular Translational Science, X. Bichat Hospital, 46 rue Henri Huchard, 75018, Paris, France; Université de Paris, Université Sorbonne Paris Nord, Paris, France. Electronic address: frederic.chaubet@univ-paris13.fr.

Didier Letourneur (D)

INSERM, U1148, Laboratory for Vascular Translational Science, X. Bichat Hospital, 46 rue Henri Huchard, 75018, Paris, France. Electronic address: didier.letourneur@inserm.fr.

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Classifications MeSH

questionsmedicales.fr › Produits chimiques inorganiques › Électrolytes › Ions › Cations › Synthesis of cationic quaternized pullulan...
questionsmedicales.fr › Composés chimiques organiques › Éthers › Composés époxy › Synthesis of cationic quaternized pullulan...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Techniques de transfert de gènes › Synthesis of cationic quaternized pullulan...
questionsmedicales.fr › Glucides › Polyosides › Glucanes › Synthesis of cationic quaternized pullulan...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules endothéliales › Cellules endothéliales de la veine ombilicale humaine › Synthesis of cationic quaternized pullulan...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Synthesis of cationic quaternized pullulan...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN non traduit › Petit ARN non traduit › microARN › Synthesis of cationic quaternized pullulan...
questionsmedicales.fr › Composés chimiques organiques › Composés onium › Composés d'ammonium quaternaire › Synthesis of cationic quaternized pullulan...
questionsmedicales.fr › Phénomènes physiques › Phénomènes magnétiques › Phénomènes électromagnétiques › Électricité › Électricité statique › Synthesis of cationic quaternized pullulan...