Isometric exercise facilitates attention to salient events in women via the noradrenergic system.
Adolescent
Adult
Aged
Aging
/ physiology
Attention
/ physiology
Auditory Perception
/ physiology
Connectome
Exercise
/ physiology
Female
Humans
Locus Coeruleus
/ diagnostic imaging
Magnetic Resonance Imaging
Melanins
/ metabolism
Middle Aged
Motor Activity
/ physiology
Nerve Net
/ diagnostic imaging
Norepinephrine
/ physiology
Parietal Lobe
/ diagnostic imaging
Prefrontal Cortex
/ diagnostic imaging
Pupil
/ physiology
Task Performance and Analysis
Young Adult
Arousal
Frontoparietal attention network
Functional connectivity
Locus coeruleus
Neuromelanin
Oddball task
Journal
NeuroImage
ISSN: 1095-9572
Titre abrégé: Neuroimage
Pays: United States
ID NLM: 9215515
Informations de publication
Date de publication:
15 04 2020
15 04 2020
Historique:
received:
25
08
2019
revised:
19
12
2019
accepted:
14
01
2020
pubmed:
25
1
2020
medline:
20
2
2021
entrez:
25
1
2020
Statut:
ppublish
Résumé
The locus coeruleus (LC) regulates attention via the release of norepinephrine (NE), with levels of tonic LC activity constraining the intensity of phasic LC responses. In the current fMRI study, we used isometric handgrip to modulate tonic LC-NE activity in older women and in young women with different hormone statuses during the time period immediately after the handgrip. During this post-handgrip time, an oddball detection task was used to probe how changes in tonic arousal influenced functional coordination between the LC and a right frontoparietal network that supports attentional selectivity. As expected, the frontoparietal network responded more to infrequent target and novel sounds than to frequent sounds. Across participants, greater LC-frontoparietal functional connectivity, pupil dilation, and faster oddball detection were all positively associated with LC MRI structural contrast from a neuromelanin-sensitive scan. Thus, LC structure was related to LC functional dynamics and attentional performance during the oddball task. We also found that handgrip influenced pupil and attentional processing during a subsequent oddball task. Handgrip decreased subsequent tonic pupil size, increased phasic pupil responses to oddball sounds, speeded oddball detection speed, and increased frontoparietal network activation, suggesting that inducing strong LC activity benefits attentional performance in the next few minutes, potentially due to reduced tonic LC activity. In addition, older women showed a similar benefit of handgrip on frontoparietal network activation as younger women, despite showing lower frontoparietal network activation overall. Together these findings suggest that a simple exercise may improve selective attention in healthy aging, at least for several minutes afterwards.
Identifiants
pubmed: 31978545
pii: S1053-8119(20)30047-1
doi: 10.1016/j.neuroimage.2020.116560
pmc: PMC7061882
mid: NIHMS1555480
pii:
doi:
Substances chimiques
Melanins
0
neuromelanin
0
Norepinephrine
X4W3ENH1CV
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
116560Subventions
Organisme : NIA NIH HHS
ID : R01 AG025340
Pays : United States
Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.
Références
Br Heart J. 1978 Nov;40(11):1216-20
pubmed: 718761
Neurochem Res. 2010 Mar;35(3):412-7
pubmed: 19795208
Circulation. 1979 Apr;59(4):637-43
pubmed: 421304
Psychophysiology. 2015 Apr;52(4):460-71
pubmed: 25369764
Life Sci. 1976 Jun 1;18(11):1315-25
pubmed: 933720
Nat Hum Behav. 2019 Nov;3(11):1203-1214
pubmed: 31501542
Neurobiol Aging. 2018 Sep;69:167-176
pubmed: 29908415
J Cogn Neurosci. 2011 Dec;23(12):4022-37
pubmed: 21671731
J Comp Neurol. 1989 Jan 8;279(2):249-71
pubmed: 2563268
Neurobiol Aging. 2016 Jan;37:117-126
pubmed: 26521135
J Psychiatr Res. 1966 Dec;4(3):189-98
pubmed: 20034169
Trends Neurosci. 2018 Apr;41(4):211-223
pubmed: 29475564
J Endocrinol. 2006 Feb;188(2):155-65
pubmed: 16461543
J Cogn Neurosci. 2011 Jul;23(7):1587-96
pubmed: 20666595
Pharmacol Biochem Behav. 1982 Apr;16(4):637-40
pubmed: 7200246
Brain Struct Funct. 2019 May;224(4):1609-1625
pubmed: 30903359
J Comp Physiol Psychol. 1970 Jul;72(1):153-60
pubmed: 5424667
Perspect Psychol Sci. 2011 Mar;6(2):114-33
pubmed: 21660127
Neuroimage. 2018 Mar;168:427-436
pubmed: 28743460
Brain Res. 1992 Mar 6;574(1-2):125-30
pubmed: 1638389
Nat Hum Behav. 2018;2:356-366
pubmed: 30320223
Physiol Behav. 2015 Apr 1;142:5-13
pubmed: 25637170
J Neurosci. 1994 Jul;14(7):4467-80
pubmed: 8027789
Gerontologist. 2018 Nov 3;58(6):1114-1125
pubmed: 29240901
Neuroimage. 2015 Jun;113:235-45
pubmed: 25791783
Neuroendocrinology. 2002 Mar;75(3):193-200
pubmed: 11914591
Neuropsychopharmacology. 2019 Jan;44(1):129-139
pubmed: 30022063
Pharmacol Biochem Behav. 1981 May;14(5):729-32
pubmed: 7195579
Neuroimage. 1999 Dec;10(6):705-15
pubmed: 10600416
Pharmacol Biochem Behav. 1982 Feb;16(2):315-9
pubmed: 7200240
Brain Res. 2019 Apr 15;1709:1-15
pubmed: 30179606
J Neural Transm (Vienna). 2006 Jun;113(6):757-67
pubmed: 16755380
J Neurosci. 2015 May 20;35(20):7866-77
pubmed: 25995472
Psychol Bull. 2005 Jul;131(4):510-32
pubmed: 16060800
Psychoneuroendocrinology. 2015 Dec;62:96-106
pubmed: 26276087
J Comp Neurol. 2004 Apr 12;471(4):446-61
pubmed: 15022263
Soc Cogn Affect Neurosci. 2014 Dec;9(12):2067-77
pubmed: 24532703
Psychoneuroendocrinology. 2013 Dec;38(12):3167-71
pubmed: 24099860
Psychophysiology. 2010 May 1;47(3):560-9
pubmed: 20070575
Nat Commun. 2016 Nov 08;7:13289
pubmed: 27824036
Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):13040-5
pubmed: 19620724
Neuron. 2016 Jan 6;89(1):221-34
pubmed: 26711118
Hum Brain Mapp. 2014 May;35(5):2265-84
pubmed: 23900833
Neuroimage. 2012 Aug 15;62(2):782-90
pubmed: 21979382
Proc Natl Acad Sci U S A. 2008 Nov 11;105(45):17567-72
pubmed: 18988735
J Pharmacol Exp Ther. 1968 Nov;164(1):122-34
pubmed: 4387046
Nat Neurosci. 2019 Feb;22(2):218-228
pubmed: 30643295
Neuroimage. 2017 Apr 15;150:329-335
pubmed: 28215623
Brain Res. 1974 Sep 6;77(2):269-79
pubmed: 4152793
Cereb Cortex. 2016 Aug;26(8):3413-27
pubmed: 26223261
MAGMA. 2017 Apr;30(2):121-125
pubmed: 27687624
Neuroscience. 1977;2(3):441-5
pubmed: 408733
Trends Cogn Sci. 2016 Mar;20(3):214-226
pubmed: 26895736
Behav Brain Funct. 2007 Jun 13;3:29
pubmed: 17567916
J Neurophysiol. 1997 Mar;77(3):1630-4
pubmed: 9084626
Psychoneuroendocrinology. 2006 Jan;31(1):137-41
pubmed: 16046076
Pharmacol Biochem Behav. 1983 Aug;19(2):287-90
pubmed: 6685313
Nat Neurosci. 2013 Aug;16(8):1146-53
pubmed: 23770566
Neuroreport. 2006 Jul 31;17(11):1215-8
pubmed: 16837857
Magn Reson Imaging. 2014 Dec;32(10):1301-6
pubmed: 25086330
J Vis. 2014 Apr 01;14(4):
pubmed: 24692319
Neuroscience. 1989;29(2):251-9
pubmed: 2471113
Auton Neurosci. 2007 Apr 30;133(1):3-18
pubmed: 17157080
Biol Psychol. 2010 May;84(2):248-56
pubmed: 20138206
Neurosci Biobehav Rev. 2017 Dec;83:325-355
pubmed: 29107830
Hum Brain Mapp. 2014 Aug;35(8):4140-54
pubmed: 24510607
Biol Psychol. 2012 Dec;91(3):342-8
pubmed: 22954623
J Exp Psychol Gen. 2005 Aug;134(3):291-307
pubmed: 16131265
Behav Brain Sci. 2016 Jan;39:e200
pubmed: 26126507
Neuroimage. 2005 Mar;25(1):294-311
pubmed: 15734364
J Neurosci. 2018 Feb 7;38(6):1558-1574
pubmed: 29301874
Psychon Bull Rev. 2017 Aug;24(4):1282-1311
pubmed: 28108977
Prog Neurobiol. 2017 Aug;155:96-119
pubmed: 26455458
PLoS One. 2013 Aug 15;8(8):e72576
pubmed: 23967320
J Pharmacol Exp Ther. 1964 Jan;143:90-5
pubmed: 14118083
J Neurosci. 2016 May 25;36(21):5699-708
pubmed: 27225761
Annu Rev Neurosci. 2005;28:403-50
pubmed: 16022602
Proc Natl Acad Sci U S A. 2018 Feb 27;115(9):2228-2233
pubmed: 29440429
J Cardiovasc Pharmacol. 1979 Mar-Apr;1(2):253-63
pubmed: 94394
Emotion. 2012 Dec;12(6):1367-72
pubmed: 22642352
Neurobiol Aging. 2014 Jun;35(6):1375-85
pubmed: 24378088
Front Neurosci. 2016 Feb 17;10:43
pubmed: 26924959
Acta Physiol Scand. 1987 Apr;129(4):489-97
pubmed: 3591371
Psychophysiology. 2006 Nov;43(6):645-52
pubmed: 17076822
Psychophysiology. 2011 Nov;48(11):1532-1543
pubmed: 21762458
Cogn Affect Behav Neurosci. 2010 May;10(2):252-69
pubmed: 20498349
Neuroimage. 2017 Dec;163:150-159
pubmed: 28943414
Brain. 2019 Sep 1;142(9):2558-2571
pubmed: 31327002
Neuropharmacology. 1973 Oct;12(10):933-8
pubmed: 4750561
Brain Imaging Behav. 2018 Apr;12(2):577-584
pubmed: 28271441
J Physiol. 1992;453:45-58
pubmed: 1464839
Prog Neurobiol. 2019 May;176:120-133
pubmed: 29772255
J Neuroendocrinol. 2000 Sep;12(9):899-909
pubmed: 10971815
J Pharmacol Exp Ther. 1966 Jun;152(3):445-57
pubmed: 4958761
Brain Res. 1979 May 18;168(1):133-50
pubmed: 36962
Neuroimage. 2009 Oct 1;47(4):1261-7
pubmed: 19524044
Clin Sci Mol Med. 1973 Dec;45(6):723-31
pubmed: 4760031
Cell Tissue Res. 1975 Jun 9;159(2):179-93
pubmed: 1149094
Neuron. 2019 Aug 21;103(4):702-718.e5
pubmed: 31227310