RNA activation in insects: The targeted activation of endogenous and exogenous genes.

Aedes / genetics Animals Animals, Genetically Modified / genetics Mosquito Vectors / genetics RNA, Double-Stranded / genetics Transcriptional Activation
Aedes aegypti Insects Mosquito RNA activation RNA interference Small RNA

Journal

Insect biochemistry and molecular biology
ISSN: 1879-0240
Titre abrégé: Insect Biochem Mol Biol
Pays: England
ID NLM: 9207282

Informations de publication

Date de publication:
04 2020
Historique:
received: 15 10 2019
revised: 10 12 2019
accepted: 15 01 2020
pubmed: 25 1 2020
medline: 7 10 2020
entrez: 25 1 2020
Statut: ppublish

Résumé

RNA activation (RNAa) is a newly emerging area of research in which dsRNA targeting promoter regions can induce the expression of the target gene. Although still in its infancy, it is already having significant impacts in several research areas in particular as cancer therapeutics. So far, the scope of RNAa has been limited to mammals and Caenorhabditis elegans with no indication of its prevalence in insects. In this study, we aimed to demonstrate the presence of RNAa in the insect dengue vector Aedes aegypti. Furthermore, we looked to uncover some details surrounding the involvement of host factors in order to present this as a new technique for insect research. The outcomes of this study provide new opportunities to further research into arthropod-borne diseases and insect biology in the same way as RNA interference.

Identifiants

DOI: 10.1016/j.ibmb.2020.103325 PMID: 31978586
pubmed: 31978586
pii: S0965-1748(20)30013-8
doi: 10.1016/j.ibmb.2020.103325
pii:
doi:

Substances chimiques

RNA, Double-Stranded 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

103325

Informations de copyright

Copyright © 2020 Elsevier Ltd. All rights reserved.

Auteurs

Lachlan De Hayr (L)

Australian Infectious Disease Research Centre, School of Biological Sciences, The University of Queensland, Brisbane, QLD, 4072, Australia.

Sultan Asad (S)

Australian Infectious Disease Research Centre, School of Biological Sciences, The University of Queensland, Brisbane, QLD, 4072, Australia.

Mazhar Hussain (M)

Australian Infectious Disease Research Centre, School of Biological Sciences, The University of Queensland, Brisbane, QLD, 4072, Australia.

Sassan Asgari (S)

Australian Infectious Disease Research Centre, School of Biological Sciences, The University of Queensland, Brisbane, QLD, 4072, Australia. Electronic address: s.asgari@uq.edu.au.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Arthropodes › Insectes › Pterygota › Neoptera › Holometabola › Diptera › Nematocera › Culicomorpha › Culicidae › Aedes › RNA activation in insects: The targeted...
questionsmedicales.fr › Eucaryotes › Animaux › RNA activation in insects: The targeted...
questionsmedicales.fr › Stades d'organismes › Organismes génétiquement modifiés › Animal génétiquement modifié › RNA activation in insects: The targeted...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Chaîne d'infection › Vecteurs de maladies › Vecteurs arthropodes › Vecteurs insectes › Vecteurs moustiques › RNA activation in insects: The targeted...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Conformation d'acide nucléique › ARN double brin › RNA activation in insects: The targeted...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Activation de la transcription › RNA activation in insects: The targeted...