Nanoscale pathways for human tooth decay - Central planar defect, organic-rich precipitate and high-angle grain boundary.

Durapatite Humans Microscopy, Electron Tooth Demineralization Tooth Remineralization
Atom probe tomography Caries Central dark line Tooth enamel

Journal

Biomaterials
ISSN: 1878-5905
Titre abrégé: Biomaterials
Pays: Netherlands
ID NLM: 8100316

Informations de publication

Date de publication:
03 2020
Historique:
received: 27 05 2019
revised: 02 12 2019
accepted: 25 12 2019
pubmed: 25 1 2020
medline: 15 5 2021
entrez: 25 1 2020
Statut: ppublish

Résumé

Understanding the pathways and mechanisms of human tooth decay is central to the development of both prophylaxes and treatments, but only limited information is presently available about the initiation of caries at the nanoscale. By combining atom probe tomography and high-resolution electron microscopy, we have found three distinct initial sites for human dental enamel dissolution: a) along the central dark line (CDL) within carbonated apatite nanocrystals, b) at organic-rich precipitates and c) along high-angle grain boundaries. 3D maps of the atoms within hydroxyapatite nanocrystallites in sound and naturally-decayed human dental enamel reveal a higher concentration of Mg and Na in the CDL. The CDL is therefore thought to provide a pathway for the exchange of ions during demineralization and remineralization. Mg and Na enrichment of the CDL also suggests that it is associated with the ribbon-like organic-rich precursor in amelogenesis. Organic-rich precipitates and high-angle grain boundaries were also shown to be more vulnerable to corrosion while low-angle grain boundaries remained intact. This is attributed to the lower crystallinity in these regions.

Identifiants

DOI: 10.1016/j.biomaterials.2019.119748 PMID: 31978841
pubmed: 31978841
pii: S0142-9612(19)30866-X
doi: 10.1016/j.biomaterials.2019.119748
pii:
doi:

Substances chimiques

Durapatite 91D9GV0Z28

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

119748

Informations de copyright

Copyright © 2019 Elsevier Ltd. All rights reserved.

Auteurs

Fan Yun (F)

School of Physics, The University of Sydney, NSW, 2006, Australia; Australian Center for Microscopy and Microanalysis, The University of Sydney, NSW, 2006, Australia; The University of Sydney Nano Institute, The University of Sydney, Sydney, NSW, 2006, Australia.

Michael V Swain (MV)

School of Aerospace, Mechanical and Mechatronic Engineering, the University of Sydney, Sydney, NSW, 2006, Australia.

Hansheng Chen (H)

School of Physics, The University of Sydney, NSW, 2006, Australia; Australian Center for Microscopy and Microanalysis, The University of Sydney, NSW, 2006, Australia; The University of Sydney Nano Institute, The University of Sydney, Sydney, NSW, 2006, Australia.

Julie Cairney (J)

Australian Center for Microscopy and Microanalysis, The University of Sydney, NSW, 2006, Australia; The University of Sydney Nano Institute, The University of Sydney, Sydney, NSW, 2006, Australia; School of Aerospace, Mechanical and Mechatronic Engineering, the University of Sydney, Sydney, NSW, 2006, Australia.

Jiangtao Qu (J)

School of Physics, The University of Sydney, NSW, 2006, Australia; Australian Center for Microscopy and Microanalysis, The University of Sydney, NSW, 2006, Australia; The University of Sydney Nano Institute, The University of Sydney, Sydney, NSW, 2006, Australia.

Gang Sha (G)

School of Materials Science and Engineering, Herbert Gleiter Institute of Nanoscience, Nanjing University of Science and Technology, Nanjing, Jiangsu, 210094, China.

Hongwei Liu (H)

Australian Center for Microscopy and Microanalysis, The University of Sydney, NSW, 2006, Australia.

Simon P Ringer (SP)

The University of Sydney Nano Institute, The University of Sydney, Sydney, NSW, 2006, Australia; School of Aerospace, Mechanical and Mechatronic Engineering, the University of Sydney, Sydney, NSW, 2006, Australia.

Yu Han (Y)

Physical Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal, 23955-6900, Saudi Arabia.

Lingmei Liu (L)

Physical Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal, 23955-6900, Saudi Arabia.

Xixiang Zhang (X)

Physical Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal, 23955-6900, Saudi Arabia.

Rongkun Zheng (R)

School of Physics, The University of Sydney, NSW, 2006, Australia; Australian Center for Microscopy and Microanalysis, The University of Sydney, NSW, 2006, Australia; The University of Sydney Nano Institute, The University of Sydney, Sydney, NSW, 2006, Australia. Electronic address: rongkun.zheng@sydney.edu.au.

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Classifications MeSH

questionsmedicales.fr › Produits chimiques inorganiques › Composés du phosphore › Acides du phosphore › Acides phosphoriques › Phosphates › Phosphates de calcium › Apatites › Hydroxyapatites › Durapatite › Nanoscale pathways for human tooth decay -...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Nanoscale pathways for human tooth decay -...
questionsmedicales.fr › Techniques d'investigation › Microscopie électronique › Nanoscale pathways for human tooth decay -...
questionsmedicales.fr › Maladies du système stomatognathique › Maladies des dents › Déminéralisation dentaire › Nanoscale pathways for human tooth decay -...
questionsmedicales.fr › Reminéralisation des dents › Nanoscale pathways for human tooth decay -...