Nuclear Export of Cyclin B Mediated by the Nup62 Complex Is Required for Meiotic Initiation in
Active Transport, Cell Nucleus
Animals
CDC2 Protein Kinase
/ metabolism
Cell Cycle Checkpoints
Cell Nucleus
/ metabolism
Cyclin B
/ metabolism
Drosophila Proteins
/ metabolism
Drosophila melanogaster
/ cytology
Karyopherins
/ metabolism
Male
Meiosis
Nuclear Pore Complex Proteins
/ metabolism
Phosphorylation
Phosphothreonine
/ metabolism
Receptors, Cytoplasmic and Nuclear
/ metabolism
Spermatids
/ cytology
Spermatocytes
/ cytology
Exportin 1 Protein
Drosophila
Nup62
cell cycle
cyclin B
male meiosis
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
22 01 2020
22 01 2020
Historique:
received:
09
12
2019
revised:
17
01
2020
accepted:
20
01
2020
entrez:
26
1
2020
pubmed:
26
1
2020
medline:
12
2
2021
Statut:
epublish
Résumé
The central channel of the nuclear pore complex plays an important role in the selective transport of proteins between the nucleus and cytoplasm. Previous studies have demonstrated that the depletion of the Nup62 complex, constructing the nuclear pore channel in premeiotic We induced dsRNAs against the nucleoporin mRNAs using the Gal4/UAS system in Drosophila. The cell cycle of the
Sections du résumé
BACKGROUND
The central channel of the nuclear pore complex plays an important role in the selective transport of proteins between the nucleus and cytoplasm. Previous studies have demonstrated that the depletion of the Nup62 complex, constructing the nuclear pore channel in premeiotic
METHODS
We induced dsRNAs against the nucleoporin mRNAs using the Gal4/UAS system in Drosophila.
RESULTS
The cell cycle of the
Identifiants
pubmed: 31979075
pii: cells9020270
doi: 10.3390/cells9020270
pmc: PMC7072204
pii:
doi:
Substances chimiques
CycB protein, Drosophila
0
Cyclin B
0
Drosophila Proteins
0
Karyopherins
0
Nuclear Pore Complex Proteins
0
Nup62 protein, Drosophila
0
Receptors, Cytoplasmic and Nuclear
0
Phosphothreonine
1114-81-4
CDC2 Protein Kinase
EC 2.7.11.22
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
There are no competing interests.
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