The Role of Dermal Fibroblasts in Nevoid Basal Cell Carcinoma Syndrome Patients: An Overview.

Animals Basal Cell Nevus Syndrome / metabolism Carcinoma, Basal Cell / metabolism Fibroblasts / metabolism Humans Patched-1 Receptor / metabolism Signal Transduction / physiology Skin Neoplasms / metabolism
Gorlin syndrome basal cell carcinoma hedgehog pathway nevoid basal cell carcinoma syndrome skin

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
22 Jan 2020
Historique:
received: 19 12 2019
revised: 17 01 2020
accepted: 19 01 2020
entrez: 26 1 2020
pubmed: 26 1 2020
medline: 7 10 2020
Statut: epublish

Résumé

Nevoid basal cell carcinoma syndrome (NBCCS), also named Gorlin syndrome, is a rare multisystem genetic disorder characterized by marked predisposition to basal cell carcinomas (BCCs), childhood medulloblastomas, maxillary keratocysts, celebral calcifications, in addition to various skeletal and soft tissue developmental abnormalities. Mutations in the tumor suppressor gene

Identifiants

DOI: 10.3390/ijms21030720 PMID: 31979112 PMC: PMC7037136
pubmed: 31979112
pii: ijms21030720
doi: 10.3390/ijms21030720
pmc: PMC7037136
pii:
doi:

Substances chimiques

Patched-1 Receptor 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Déclaration de conflit d'intérêts

Authors have no conflicts of interest to disclose.

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Auteurs

Barbara Bellei (B)

Laboratory of Cutaneous Physiopathology and Integrated Center of Metabolomics Research, San Gallicano Dermatologic Institute, IRCCS, 00100 Rome, Italy.

Silvia Caputo (S)

Laboratory of Cutaneous Physiopathology and Integrated Center of Metabolomics Research, San Gallicano Dermatologic Institute, IRCCS, 00100 Rome, Italy.

Anna Carbone (A)

Oncologic and Preventative Dermatology, San Gallicano Dermatological Institute, IRCCS, 00100 Rome, Italy.

Vitaliano Silipo (V)

Oncologic and Preventative Dermatology, San Gallicano Dermatological Institute, IRCCS, 00100 Rome, Italy.

Federica Papaccio (F)

Laboratory of Cutaneous Physiopathology and Integrated Center of Metabolomics Research, San Gallicano Dermatologic Institute, IRCCS, 00100 Rome, Italy.

Mauro Picardo (M)

Laboratory of Cutaneous Physiopathology and Integrated Center of Metabolomics Research, San Gallicano Dermatologic Institute, IRCCS, 00100 Rome, Italy.

Laura Eibenschutz (L)

Oncologic and Preventative Dermatology, San Gallicano Dermatological Institute, IRCCS, 00100 Rome, Italy.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › The Role of Dermal Fibroblasts in Nevoid Basal...
questionsmedicales.fr › Malformations et maladies congénitales, héréditaires et néonatales › Maladies génétiques congénitales › Syndromes néoplasiques héréditaires › Naevomatose basocellulaire › The Role of Dermal Fibroblasts in Nevoid Basal...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs épithéliales épidermoïdes et glandulaires › Tumeurs basocellulaires › Carcinome basocellulaire › The Role of Dermal Fibroblasts in Nevoid Basal...
questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Fibroblastes › The Role of Dermal Fibroblasts in Nevoid Basal...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › The Role of Dermal Fibroblasts in Nevoid Basal...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines suppresseurs de tumeurs › Récepteurs patched › Récepteur Patched-1 › The Role of Dermal Fibroblasts in Nevoid Basal...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › The Role of Dermal Fibroblasts in Nevoid Basal...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Tumeurs cutanées › The Role of Dermal Fibroblasts in Nevoid Basal...