Composite Nanogels Based on Zeolite-Poly(ethylene glycol) Diacrylate for Controlled Drug Delivery.
5-FU
composite nanogels
controlled release
mini-emulsion polymerization
poly(ethylene glycol) diacrylate
zeolite
Journal
Nanomaterials (Basel, Switzerland)
ISSN: 2079-4991
Titre abrégé: Nanomaterials (Basel)
Pays: Switzerland
ID NLM: 101610216
Informations de publication
Date de publication:
22 Jan 2020
22 Jan 2020
Historique:
received:
02
12
2019
revised:
11
01
2020
accepted:
14
01
2020
entrez:
26
1
2020
pubmed:
26
1
2020
medline:
26
1
2020
Statut:
epublish
Résumé
This study presents the design of novel composites nanogels, based on poly(ethylene glycol) diacrylate and natural zeolite particles, that are able to act as materials with controlled drug delivery properties. Natural zeolite‒nanogels composite, with varying zeolite contents, were obtained by an inverse mini-emulsion technique and loaded with 5-fluorouracil, a widely used chemotherapeutic drug. Herein, the possibility of adjusting final properties by means of modifying the preparation conditions was investigated. The prepared composite nanogels are characterized by dynamic light scattering (DLS), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), and thermogravimetric analysis (TGA). In light of this tunable drug-loading capability, swelling behaviour, and cytotoxicity, these composite nanogels could be highly attractive as drug reservoirs.
Identifiants
pubmed: 31979174
pii: nano10020195
doi: 10.3390/nano10020195
pmc: PMC7075022
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : ERA-NET Cofund WaterWorks2015 Call
ID : 39/2017-ProWsper
Organisme : PN III- Human Resources Program -YOUNG RESEARCH TEAMS -PN-III-P1-1.1- TE-2016-1876
ID : 91/2018-PLANano
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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