Recent Advances in Electrochemical and Optical Biosensors Designed for Detection of Interleukin 6.


Journal

Sensors (Basel, Switzerland)
ISSN: 1424-8220
Titre abrégé: Sensors (Basel)
Pays: Switzerland
ID NLM: 101204366

Informations de publication

Date de publication:
23 Jan 2020
Historique:
received: 11 11 2019
revised: 06 12 2019
accepted: 18 12 2019
entrez: 26 1 2020
pubmed: 26 1 2020
medline: 22 9 2020
Statut: epublish

Résumé

Interleukin 6 (IL-6), being a major component of homeostasis, immunomodulation, and hematopoiesis, manifests multiple pathological conditions when upregulated in response to viral, microbial, carcinogenic, or autoimmune stimuli. High fidelity immunosensors offer real-time monitoring of IL-6 and facilitate early prognosis of life-threatening diseases. Different approaches to augment robustness and enhance overall performance of biosensors have been demonstrated over the past few years. Electrochemical- and fluorescence-based detection methods with integrated electronics have been subjects of intensive research due to their ability to offer a better signal-to-noise ratio, high specificity, ultra-sensitivity, and wide dynamic range. In this review, the pleiotropic role of IL-6 and its clinical significance is discussed in detail, followed by detection schemes devised so far for their quantitative analysis. A critical review on underlying signal amplification strategies and performance of electrochemical and optical biosensors is presented. In conclusion, we discuss the reliability and feasibility of the proposed detection technologies for commercial applications.

Identifiants

pubmed: 31979357
pii: s20030646
doi: 10.3390/s20030646
pmc: PMC7038342
pii:
doi:

Substances chimiques

Interleukin-6 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Higher Education Commision, Pakistan
ID : IRSIP 2019

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Auteurs

Munezza Ata Khan (MA)

School of Chemical and Materials Engineering, National University of Sciences & Technology, H-12, 44000 Islamabad, Pakistan.
School of Materials Sciences & Engineering, Nanyang Technological University, Nanyang Avenue, Singapore 639798, Singapore.

Mohammad Mujahid (M)

School of Chemical and Materials Engineering, National University of Sciences & Technology, H-12, 44000 Islamabad, Pakistan.
Pak-Austria Fachhochshule, Institute of Applied Sciences & Technology, Khanpur Road, Mang, Haripur 22650, Pakistan.

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