The Endocannabinoid System: A Target for Cancer Treatment.
Animals
Antineoplastic Agents
/ pharmacology
Cannabinoids
/ metabolism
Cell Movement
/ drug effects
Cell Proliferation
/ drug effects
Endocannabinoids
/ metabolism
Female
Gastrointestinal Neoplasms
/ drug therapy
Humans
Male
Neoplasms
/ drug therapy
Neovascularization, Pathologic
/ drug therapy
Receptors, Cannabinoid
/ drug effects
Signal Transduction
/ drug effects
Cannabinoids
angiogenesis
cancer stem cell
metastasis
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
23 Jan 2020
23 Jan 2020
Historique:
received:
14
12
2019
revised:
17
01
2020
accepted:
20
01
2020
entrez:
26
1
2020
pubmed:
26
1
2020
medline:
18
11
2020
Statut:
epublish
Résumé
In recent years, the endocannabinoid system has received great interest as a potential therapeutic target in numerous pathological conditions. Cannabinoids have shown an anticancer potential by modulating several pathways involved in cell growth, differentiation, migration, and angiogenesis. However, the therapeutic efficacy of cannabinoids is limited to the treatment of chemotherapy-induced symptoms or cancer pain, but their use as anticancer drugs in chemotherapeutic protocols requires further investigation. In this paper, we reviewed the role of cannabinoids in the modulation of signaling mechanisms implicated in tumor progression.
Identifiants
pubmed: 31979368
pii: ijms21030747
doi: 10.3390/ijms21030747
pmc: PMC7037210
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Cannabinoids
0
Endocannabinoids
0
Receptors, Cannabinoid
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : AIRC
ID : IG 18999
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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