Constitutive Activation of Guanylate Cyclase by the G86R GCAP1 Variant Is Due to "Locking" Cation-π Interactions that Impair the Activator-to-Inhibitor Structural Transition.
Amino Acids, Aromatic
/ chemistry
Calcium
/ metabolism
Cations
/ chemistry
Circular Dichroism
Cone Dystrophy
/ genetics
Dynamic Light Scattering
Guanylate Cyclase
/ metabolism
Guanylate Cyclase-Activating Proteins
/ chemistry
HEK293 Cells
Humans
Molecular Dynamics Simulation
Mutation, Missense
Protein Binding
Protein Conformation
Recombinant Proteins
Thermodynamics
cone dystrophy
guanylate cyclase-activating protein 1
neuronal calcium sensor
retinal guanylate cyclase
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
23 Jan 2020
23 Jan 2020
Historique:
received:
09
12
2019
revised:
18
01
2020
accepted:
20
01
2020
entrez:
26
1
2020
pubmed:
26
1
2020
medline:
18
11
2020
Statut:
epublish
Résumé
Guanylate Cyclase activating protein 1 (GCAP1) mediates the Ca
Identifiants
pubmed: 31979372
pii: ijms21030752
doi: 10.3390/ijms21030752
pmc: PMC7037459
pii:
doi:
Substances chimiques
Amino Acids, Aromatic
0
Cations
0
GUCA1A protein, human
0
Guanylate Cyclase-Activating Proteins
0
Recombinant Proteins
0
Guanylate Cyclase
EC 4.6.1.2
Calcium
SY7Q814VUP
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Fondazione Telethon
ID : GGP16010
Organisme : Deutsche Forschungsgemeinschaft
ID : GRK1885
Organisme : Deutscher Akademischer Austauschdienst
ID : to S.A.
Déclaration de conflit d'intérêts
The authors declare no conflict of interests.
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