Sonic Hedgehog Signaling in Organogenesis, Tumors, and Tumor Microenvironments.
Cerebellar Neoplasms
/ genetics
Gallbladder Neoplasms
/ genetics
Hedgehog Proteins
/ genetics
Humans
Liver Neoplasms
/ genetics
Medulloblastoma
/ genetics
Neoplasms
/ metabolism
Neoplastic Stem Cells
/ metabolism
Neovascularization, Pathologic
/ genetics
Neovascularization, Physiologic
/ genetics
Organogenesis
/ genetics
Pancreatic Neoplasms
/ genetics
Signal Transduction
/ genetics
Tumor Microenvironment
/ genetics
cancer stem cells
hedgehog
smoothened
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
23 Jan 2020
23 Jan 2020
Historique:
received:
27
12
2019
revised:
20
01
2020
accepted:
20
01
2020
entrez:
26
1
2020
pubmed:
26
1
2020
medline:
18
11
2020
Statut:
epublish
Résumé
During mammalian embryonic development, primary cilia transduce and regulate several signaling pathways. Among the various pathways, Sonic hedgehog (SHH) is one of the most significant. SHH signaling remains quiescent in adult mammalian tissues. However, in multiple adult tissues, it becomes active during differentiation, proliferation, and maintenance. Moreover, aberrant activation of SHH signaling occurs in cancers of the skin, brain, liver, gallbladder, pancreas, stomach, colon, breast, lung, prostate, and hematological malignancies. Recent studies have shown that the tumor microenvironment or stroma could affect tumor development and metastasis. One hypothesis has been proposed, claiming that the pancreatic epithelia secretes SHH that is essential in establishing and regulating the pancreatic tumor microenvironment in promoting cancer progression. The SHH signaling pathway is also activated in the cancer stem cells (CSC) of several neoplasms. The self-renewal of CSC is regulated by the SHH/Smoothened receptor (SMO)/Glioma-associated oncogene homolog I (GLI) signaling pathway. Combined use of SHH signaling inhibitors and chemotherapy/radiation therapy/immunotherapy is therefore key in targeting CSCs.
Identifiants
pubmed: 31979397
pii: ijms21030758
doi: 10.3390/ijms21030758
pmc: PMC7037908
pii:
doi:
Substances chimiques
Hedgehog Proteins
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Far Eastern Memorial Hospital
ID : FEMH-2019-C-002
Organisme : Far Eastern Memorial Hospital
ID : FEMH-2019-C-078
Organisme : Ministry of Science and Technology, Taiwan
ID : MOST 108-2314-B-418-001
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