Sex differences in neurodevelopmental abnormalities caused by early-life anaesthesia exposure: a narrative review.
Anesthetics
/ adverse effects
Animals
Anxiety
/ chemically induced
Apoptosis
/ drug effects
Attention Deficit Disorder with Hyperactivity
/ chemically induced
Cognition Disorders
/ chemically induced
DNA Methylation
Female
Humans
Male
Neurodevelopmental Disorders
/ chemically induced
Neurotoxicity Syndromes
/ etiology
Sex Characteristics
anaesthesia
general anaesthesia
hormones
infant anaesthesia
neurodevelopment
neurotoxicity
rodents
sex difference
Journal
British journal of anaesthesia
ISSN: 1471-6771
Titre abrégé: Br J Anaesth
Pays: England
ID NLM: 0372541
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
07
12
2019
revised:
15
12
2019
accepted:
23
12
2019
pubmed:
26
1
2020
medline:
12
3
2020
entrez:
26
1
2020
Statut:
ppublish
Résumé
Exposure to anaesthetic drugs during the fetal or neonatal period induces widespread neuronal apoptosis in the brains of rodents and non-human primates. Hundreds of published preclinical studies and nearly 20 clinical studies have documented cognitive and behavioural deficits many months or years later, raising the spectre that early life anaesthesia exposure is a long-term, perhaps permanent, insult that might affect the quality of life of millions of humans. Although the phenomenon of anaesthesia-induced developmental neurotoxicity is well characterised, there are important and lingering questions pertaining to sex differences and neurodevelopmental sequelae that might occur differentially in females and males. We review the relevant literature on sex differences in the field of anaesthesia-induced developmental neurotoxicity, and present an emerging pattern of potential sex-dependent neurodevelopmental abnormalities in rodent models of human infant anaesthesia exposure.
Identifiants
pubmed: 31980157
pii: S0007-0912(19)31022-0
doi: 10.1016/j.bja.2019.12.032
pmc: PMC7050624
pii:
doi:
Substances chimiques
Anesthetics
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e81-e91Subventions
Organisme : NICHD NIH HHS
ID : R01 HD044517
Pays : United States
Organisme : NICHD NIH HHS
ID : R21 HD080281
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM118197
Pays : United States
Informations de copyright
Copyright © 2019 British Journal of Anaesthesia. Published by Elsevier Ltd. All rights reserved.
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