Ex vivo expansion of regulatory T cells from abdominal aortic aneurysm patients inhibits aneurysm in humanized murine model.
Adoptive Transfer
Aged
Animals
Aorta, Abdominal
/ immunology
Aortic Aneurysm, Abdominal
/ chemically induced
Calcium Chloride
Case-Control Studies
Cell Proliferation
Cell Separation
Cells, Cultured
Dilatation, Pathologic
Disease Models, Animal
Female
Homeodomain Proteins
/ genetics
Humans
Male
Mice, Inbred C57BL
Mice, Knockout
T-Lymphocytes, Regulatory
/ immunology
Aneurysm
Aorta
Inflammation
Regulatory T cells
Journal
Journal of vascular surgery
ISSN: 1097-6809
Titre abrégé: J Vasc Surg
Pays: United States
ID NLM: 8407742
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
received:
16
04
2019
accepted:
29
08
2019
pubmed:
26
1
2020
medline:
20
1
2021
entrez:
26
1
2020
Statut:
ppublish
Résumé
Abdominal aortic aneurysm (AAA) is a chronic inflammatory disease. Studies of human aneurysm tissue demonstrate dense inflammatory cell infiltrates with CD4 Circulating Treg population in AAA patients and age- and gender-matched controls were determined by real-time polymerase chain reaction and flow cytometry. To create humanized murine model of AAA, irradiated Rag1-deficient (Rag1 In human peripheral blood mononuclear cells, the proportion of Tregs are decreased in AAA patients compared with matched control patients with significant vascular disease. We first validated the role of Tregs in the CaCl These data suggest that the ex vivo expansion of human Tregs may be a potential therapeutic strategy for inhibiting progression of AAA.
Identifiants
pubmed: 31980239
pii: S0741-5214(19)32537-6
doi: 10.1016/j.jvs.2019.08.285
pmc: PMC10690961
mid: NIHMS1551536
pii:
doi:
Substances chimiques
Homeodomain Proteins
0
RAG-1 protein
128559-51-3
Calcium Chloride
M4I0D6VV5M
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1087-1096.e1Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL062400
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL130623
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.
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