Use of ganglion cell layer analysis for diagnosing anti-glycoprotein neuromyelitis optica of oligodendrocyte myelin.
Uso del análisis de la capa de células ganglionares para el diagnóstico en la neuromielitis óptica anti-glucoproteína de la mielina del oligodendrocito.
Anti-myelin oligodendrocyte glycoprotein antibodies
Anticuerpos anti-glucoproteína de la mielina del oligodendrocito
Células ganglionares
Ganglion cells
Neuromielitis óptica
Neuromyelitis optica
Journal
Archivos de la Sociedad Espanola de Oftalmologia
ISSN: 2173-5794
Titre abrégé: Arch Soc Esp Oftalmol (Engl Ed)
Pays: Spain
ID NLM: 101715860
Informations de publication
Date de publication:
Mar 2020
Mar 2020
Historique:
received:
31
07
2019
revised:
20
11
2019
accepted:
24
11
2019
pubmed:
26
1
2020
medline:
1
1
2021
entrez:
26
1
2020
Statut:
ppublish
Résumé
The case concerns a 26-year-old patient with bilateral recurrent optic neuritis episodes in the context of suspected neuromyelitis optica. In the first outbreak, she had greatly impaired visual acuity of the left eye, as well as seeing ganglion cell layer damage in both eyes in the optic coherence tomography, with evidence of a possible extensive lesion in the optic chiasma. Likewise, MRI with contrast showed a great involvement of the left optic nerve that compromises the chiasma increasing the suspicion of a neuromyelitis origin. Althogh the anti-myelin oligodendrocyte glycoprotein (MOG) and anti-AQP4 (aquaporin-4) antibodies were negative at first, bilateral involvement of the ganglion cells suggested an extensive lesion that is more characteristic of seropositive anti-MOG neuromyelitis.
Identifiants
pubmed: 31980323
pii: S0365-6691(19)30357-0
doi: 10.1016/j.oftal.2019.11.011
pii:
doi:
Substances chimiques
Myelin-Oligodendrocyte Glycoprotein
0
Types de publication
Case Reports
Journal Article
Langues
eng
spa
Sous-ensembles de citation
IM
Pagination
146-149Informations de copyright
Copyright © 2019 Sociedad Española de Oftalmología. Publicado por Elsevier España, S.L.U. All rights reserved.