Regulatory T-cell therapy in Crohn's disease: challenges and advances.
Crohn's disease
T lymphocytes
immunology
immunoregulation
intestinal T cells
Journal
Gut
ISSN: 1468-3288
Titre abrégé: Gut
Pays: England
ID NLM: 2985108R
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
received:
12
09
2019
revised:
21
11
2019
accepted:
19
12
2019
pubmed:
26
1
2020
medline:
4
11
2020
entrez:
26
1
2020
Statut:
ppublish
Résumé
The prevalence of IBD is rising in the Western world. Despite an increasing repertoire of therapeutic targets, a significant proportion of patients suffer chronic morbidity. Studies in mice and humans have highlighted the critical role of regulatory T cells in immune homeostasis, with defects in number and suppressive function of regulatory T cells seen in patients with Crohn's disease. We review the function of regulatory T cells and the pathways by which they exert immune tolerance in the intestinal mucosa. We explore the principles and challenges of manufacturing a cell therapy, and discuss clinical trial evidence to date for their safety and efficacy in human disease, with particular focus on the development of a regulatory T-cell therapy for Crohn's disease.
Identifiants
pubmed: 31980447
pii: gutjnl-2019-319850
doi: 10.1136/gutjnl-2019-319850
pmc: PMC7229901
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
942-952Subventions
Organisme : Medical Research Council
ID : MR/T005564/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S00033X/1
Pays : United Kingdom
Organisme : Department of Health
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N006445/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/M003493/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0802068
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R001413/1
Pays : United Kingdom
Informations de copyright
© Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: PMI is the Chief Investigator and GML is the Chief Scientific Investigator on the Medical Research Council-funded TRIBUTE trial of Treg immunotherapy in CD (ClinicalTrials.gov NCT03185000).
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