Spatial attention enhances network, cellular and subthreshold responses in mouse visual cortex.
Action Potentials
/ physiology
Animals
Arousal
/ physiology
Attention
/ physiology
Behavior, Animal
/ physiology
Male
Mice, Inbred C57BL
Motivation
Neurons
/ physiology
Photic Stimulation
Pupil
/ physiology
Sensory Thresholds
/ physiology
Space Perception
/ physiology
Task Performance and Analysis
Visual Cortex
/ physiology
Visual Fields
/ physiology
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
24 01 2020
24 01 2020
Historique:
received:
31
05
2019
accepted:
02
01
2020
entrez:
26
1
2020
pubmed:
26
1
2020
medline:
9
4
2020
Statut:
epublish
Résumé
Internal brain states strongly modulate sensory processing during behaviour. Studies of visual processing in primates show that attention to space selectively improves behavioural and neural responses to stimuli at the attended locations. Here we develop a visual spatial task for mice that elicits behavioural improvements consistent with the effects of spatial attention, and simultaneously measure network, cellular, and subthreshold activity in primary visual cortex. During trial-by-trial behavioural improvements, local field potential (LFP) responses to stimuli detected inside the receptive field (RF) strengthen. Moreover, detection inside the RF selectively enhances excitatory and inhibitory neuron responses to task-irrelevant stimuli and suppresses noise correlations and low frequency LFP fluctuations. Whole-cell patch-clamp recordings reveal that detection inside the RF increases synaptic activity that depolarizes membrane potential responses at the behaviorally relevant location. Our study establishes that mice display fundamental signatures of visual spatial attention spanning behavioral, network, cellular, and synaptic levels, providing new insight into rapid cognitive enhancement of sensory signals in visual cortex.
Identifiants
pubmed: 31980628
doi: 10.1038/s41467-020-14355-4
pii: 10.1038/s41467-020-14355-4
pmc: PMC6981183
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
505Subventions
Organisme : NINDS NIH HHS
ID : R01 NS107968
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS109978
Pays : United States
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