Erythroid differentiation regulator-1 induced by microbiota in early life drives intestinal stem cell proliferation and regeneration.
Animals
Cell Proliferation
/ genetics
Colitis
/ chemically induced
Dextran Sulfate
Epithelial Cells
/ metabolism
Gene Expression Regulation
Germ-Free Life
Humans
Luciferases
/ metabolism
Membrane Proteins
/ metabolism
Mice, Inbred C57BL
Microbiota
/ genetics
Organoids
/ metabolism
Receptors, G-Protein-Coupled
/ metabolism
Regeneration
Stem Cells
/ cytology
Tumor Suppressor Proteins
/ metabolism
Wnt Signaling Pathway
/ genetics
Wound Healing
/ genetics
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
24 01 2020
24 01 2020
Historique:
received:
21
03
2019
accepted:
22
12
2019
entrez:
26
1
2020
pubmed:
26
1
2020
medline:
9
4
2020
Statut:
epublish
Résumé
Gut microbiota and their metabolites are instrumental in regulating intestinal homeostasis. However, early-life microbiota associated influences on intestinal development remain incompletely understood. Here we demonstrate that co-housing of germ-free (GF) mice with specific-pathogen free (SPF) mice at weaning (exGF) results in altered intestinal gene expression. Our results reveal that one highly differentially expressed gene, erythroid differentiation regulator-1 (Erdr1), is induced during development in SPF but not GF or exGF mice and localizes to Lgr5
Identifiants
pubmed: 31980634
doi: 10.1038/s41467-019-14258-z
pii: 10.1038/s41467-019-14258-z
pmc: PMC6981263
doi:
Substances chimiques
Lgr5 protein, mouse
0
Membrane Proteins
0
Receptors, G-Protein-Coupled
0
Tumor Suppressor Proteins
0
erythroid differentiation regulator 1, mouse
0
Dextran Sulfate
9042-14-2
Luciferases
EC 1.13.12.-
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
513Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK055679
Pays : United States
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