Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS
Cell Line, Tumor
Cell Transformation, Neoplastic
/ pathology
Colorectal Neoplasms
/ metabolism
ErbB Receptors
/ metabolism
Humans
Mutation
/ genetics
Phosphorylation
Prognosis
Protein Interaction Maps
Proto-Oncogene Proteins p21(ras)
/ genetics
Survival Analysis
bcl-Associated Death Protein
/ metabolism
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
24 01 2020
24 01 2020
Historique:
received:
11
05
2019
accepted:
05
12
2019
entrez:
26
1
2020
pubmed:
26
1
2020
medline:
9
4
2020
Statut:
epublish
Résumé
Protein-protein-interaction networks (PPINs) organize fundamental biological processes, but how oncogenic mutations impact these interactions and their functions at a network-level scale is poorly understood. Here, we analyze how a common oncogenic KRAS mutation (KRAS
Identifiants
pubmed: 31980649
doi: 10.1038/s41467-019-14224-9
pii: 10.1038/s41467-019-14224-9
pmc: PMC6981206
doi:
Substances chimiques
KRAS protein, human
0
bcl-Associated Death Protein
0
ErbB Receptors
EC 2.7.10.1
Proto-Oncogene Proteins p21(ras)
EC 3.6.5.2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
499Références
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