Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS


Journal

Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555

Informations de publication

Date de publication:
24 01 2020
Historique:
received: 11 05 2019
accepted: 05 12 2019
entrez: 26 1 2020
pubmed: 26 1 2020
medline: 9 4 2020
Statut: epublish

Résumé

Protein-protein-interaction networks (PPINs) organize fundamental biological processes, but how oncogenic mutations impact these interactions and their functions at a network-level scale is poorly understood. Here, we analyze how a common oncogenic KRAS mutation (KRAS

Identifiants

pubmed: 31980649
doi: 10.1038/s41467-019-14224-9
pii: 10.1038/s41467-019-14224-9
pmc: PMC6981206
doi:

Substances chimiques

KRAS protein, human 0
bcl-Associated Death Protein 0
ErbB Receptors EC 2.7.10.1
Proto-Oncogene Proteins p21(ras) EC 3.6.5.2

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

499

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Auteurs

Susan A Kennedy (SA)

Systems Biology Ireland, University College Dublin, Dublin, Ireland.

Mohamed-Ali Jarboui (MA)

Institute for Ophthalmic Research, University of Tübingen, Tübingen, Germany.
Werner Siemens Imaging Center, University of Tübingen, Tübingen, Germany.

Sriganesh Srihari (S)

EMBL Australia Group, South Australian Health and Medical Research Institute, Adelaide, SA, 5000, Australia.
QIMR-Berghofer Medical Research Institute, Brisbane, QLD, 4006, Australia.

Cinzia Raso (C)

Systems Biology Ireland, University College Dublin, Dublin, Ireland.

Kenneth Bryan (K)

EMBL Australia Group, South Australian Health and Medical Research Institute, Adelaide, SA, 5000, Australia.

Layal Dernayka (L)

Institute for Ophthalmic Research, University of Tübingen, Tübingen, Germany.

Theodosia Charitou (T)

Systems Biology Ireland, University College Dublin, Dublin, Ireland.
EMBL Australia Group, South Australian Health and Medical Research Institute, Adelaide, SA, 5000, Australia.

Manuel Bernal-Llinares (M)

EMBL Australia Group, South Australian Health and Medical Research Institute, Adelaide, SA, 5000, Australia.

Carlos Herrera-Montavez (C)

Systems Biology Ireland, University College Dublin, Dublin, Ireland.

Aleksandar Krstic (A)

Systems Biology Ireland, University College Dublin, Dublin, Ireland.

David Matallanas (D)

Systems Biology Ireland, University College Dublin, Dublin, Ireland.

Max Kotlyar (M)

Krembil Research Institute, University Health Network, Toronto, Canada.

Igor Jurisica (I)

Krembil Research Institute, University Health Network, Toronto, Canada.
Departments of Medical Biophysics and Computer Science, University of Toronto, Toronto, Canada.
Institute of Neuroimmunology, Slovak Academy of Sciences, Bratislava, Slovak Republic.

Jasna Curak (J)

Donnelly Centre, University of Toronto, Toronto, Canada.
Department of Biochemistry, University of Toronto, Toronto, Canada.
Department of Molecular Genetics, University of Toronto, Toronto, Canada.

Victoria Wong (V)

Donnelly Centre, University of Toronto, Toronto, Canada.
Department of Biochemistry, University of Toronto, Toronto, Canada.
Department of Molecular Genetics, University of Toronto, Toronto, Canada.

Igor Stagljar (I)

Donnelly Centre, University of Toronto, Toronto, Canada.
Department of Biochemistry, University of Toronto, Toronto, Canada.
Department of Molecular Genetics, University of Toronto, Toronto, Canada.
Mediterranean Institute for Life Sciences, Split, Croatia.

Thierry LeBihan (T)

Synthetic and Systems Biology, University of Edinburgh, Edinburgh, UK.

Lisa Imrie (L)

Synthetic and Systems Biology, University of Edinburgh, Edinburgh, UK.

Priyanka Pillai (P)

EMBL Australia Group, South Australian Health and Medical Research Institute, Adelaide, SA, 5000, Australia.

Miriam A Lynn (MA)

EMBL Australia Group, South Australian Health and Medical Research Institute, Adelaide, SA, 5000, Australia.

Erik Fasterius (E)

School of Biotechnology, KTH Royal Institute of Technology, Stockholm, Sweden.

Cristina Al-Khalili Szigyarto (C)

School of Biotechnology, KTH Royal Institute of Technology, Stockholm, Sweden.
Science for Life Laboratory, KTH Royal Institute of Technology, Stockholm, Sweden.

James Breen (J)

School of Biological Sciences, University of Adelaide Bioinformatics Hub, Adelaide, SA, Australia.
Computational & Systems Biology Program, South Australian Health and Medical Research Institute, Adelaide, SA, Australia.

Christina Kiel (C)

Systems Biology Ireland, University College Dublin, Dublin, Ireland.
Centre for Genomic Regulation, Barcelona Institute of Science and Technology, Barcelona, Spain.
Conway Institute, University College Dublin, Dublin, Ireland.

Luis Serrano (L)

Centre for Genomic Regulation, Barcelona Institute of Science and Technology, Barcelona, Spain.

Nora Rauch (N)

Systems Biology Ireland, University College Dublin, Dublin, Ireland.

Oleksii Rukhlenko (O)

Systems Biology Ireland, University College Dublin, Dublin, Ireland.

Boris N Kholodenko (BN)

Systems Biology Ireland, University College Dublin, Dublin, Ireland.
Conway Institute, University College Dublin, Dublin, Ireland.
Department of Pharmacology, Yale University School of Medicine, New Haven, CT, USA.

Luis F Iglesias-Martinez (LF)

Systems Biology Ireland, University College Dublin, Dublin, Ireland.

Colm J Ryan (CJ)

Systems Biology Ireland, University College Dublin, Dublin, Ireland.
School of Computer Science, University College Dublin, Dublin, Ireland.

Ruth Pilkington (R)

Systems Biology Ireland, University College Dublin, Dublin, Ireland.

Patrizia Cammareri (P)

Cancer Research UK Beatson Institute, Glasgow, UK.

Owen Sansom (O)

Cancer Research UK Beatson Institute, Glasgow, UK.
Institute of Cancer Studies, Glasgow University, Glasgow, UK.

Steven Shave (S)

School of Biological Sciences and School of Biomedical Sciences, University of Edinburgh, Edinburgh, UK.

Manfred Auer (M)

School of Biological Sciences and School of Biomedical Sciences, University of Edinburgh, Edinburgh, UK.

Nicola Horn (N)

Institute for Ophthalmic Research, University of Tübingen, Tübingen, Germany.

Franziska Klose (F)

Institute for Ophthalmic Research, University of Tübingen, Tübingen, Germany.

Marius Ueffing (M)

Institute for Ophthalmic Research, University of Tübingen, Tübingen, Germany.

Karsten Boldt (K)

Institute for Ophthalmic Research, University of Tübingen, Tübingen, Germany. karsten.boldt@uni-tuebingen.de.

David J Lynn (DJ)

EMBL Australia Group, South Australian Health and Medical Research Institute, Adelaide, SA, 5000, Australia. david.lynn@sahmri.com.
College of Medicine and Public Health, Flinders University, Bedford Park, SA, 5042, Australia. david.lynn@sahmri.com.

Walter Kolch (W)

Systems Biology Ireland, University College Dublin, Dublin, Ireland. walter.kolch@ucd.ie.
Conway Institute, University College Dublin, Dublin, Ireland. walter.kolch@ucd.ie.
School of Medicine, University College Dublin, Dublin, Ireland. walter.kolch@ucd.ie.

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