Transcriptional control of hyphal morphogenesis in Candida albicans.
C. albicans
environmental signals
hyphae
morphogenesis
transcription factor(s)
Journal
FEMS yeast research
ISSN: 1567-1364
Titre abrégé: FEMS Yeast Res
Pays: England
ID NLM: 101085384
Informations de publication
Date de publication:
01 02 2020
01 02 2020
Historique:
received:
17
06
2019
accepted:
31
01
2020
pubmed:
26
1
2020
medline:
17
4
2021
entrez:
26
1
2020
Statut:
ppublish
Résumé
Candida albicans is a multimorphic commensal organism and opportunistic fungal pathogen in humans. A morphological switch between unicellular budding yeast and multicellular filamentous hyphal growth forms plays a vital role in the virulence of C. albicans, and this transition is regulated in response to a range of environmental cues that are encountered in distinct host niches. Many unique transcription factors contribute to the transcriptional regulatory network that integrates these distinct environmental cues and determines which phenotypic state will be expressed. These hyphal morphogenesis regulators have been extensively investigated, and represent an increasingly important focus of study, due to their central role in controlling a key C. albicans virulence attribute. This review provides a succinct summary of the transcriptional regulatory factors and environmental signals that control hyphal morphogenesis in C. albicans.
Identifiants
pubmed: 31981355
pii: 5715912
doi: 10.1093/femsyr/foaa005
pmc: PMC7000152
pii:
doi:
Substances chimiques
Fungal Proteins
0
Transcription Factors
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : R15 AI137975
Pays : United States
Informations de copyright
© FEMS 2020.
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