Prognostic significance of PD-L1 expression on cell-surface vimentin-positive circulating tumor cells in gastric cancer patients.

B7-H1 Antigen / analysis Biomarkers, Tumor / analysis Female Humans Male Middle Aged Neoplastic Cells, Circulating / pathology Prognosis Stomach Neoplasms / diagnosis Vimentin / analysis
cell-surface vimentin circulating tumor cells epithelial-mesenchymal transition gastric cancer programmed cell death ligand 1

Journal

Molecular oncology
ISSN: 1878-0261
Titre abrégé: Mol Oncol
Pays: United States
ID NLM: 101308230

Informations de publication

Date de publication:
04 2020
Historique:
received: 08 05 2019
revised: 05 01 2020
accepted: 20 01 2020
pubmed: 26 1 2020
medline: 2 2 2021
entrez: 26 1 2020
Statut: ppublish

Résumé

Although circulating tumor cells (CTCs) have shown promise as potential biomarkers for diagnostic and prognostic assessment in gastric cancer (GC), determining the predictive and prognostic value of programmed death-ligand 1 (PD-L1)-positive CTCs in patients with GC is a challenge. Here, we identified that the expression of total vimentin (VIM) protein was positively correlated with PD-L1 and inhibited CD8

Identifiants

DOI: 10.1002/1878-0261.12643 PMID: 31981446 PMC: PMC7138401
pubmed: 31981446
doi: 10.1002/1878-0261.12643
pmc: PMC7138401
doi:

Substances chimiques

B7-H1 Antigen 0
Biomarkers, Tumor 0
CD274 protein, human 0
Vimentin 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

865-881

Informations de copyright

© 2020 The Authors. Published by FEBS Press and John Wiley & Sons Ltd.

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Auteurs

Mengyuan Liu (M)

Department of Gastroenterology, The First Affiliated Hospital of China Medical University, Shenyang, China.
Department of Endoscopy, The First Affiliated Hospital of China Medical University, Shenyang, China.

Ruoyu Wang (R)

Department of Oncology, Affiliated Zhongshan Hospital of Dalian University, China.
The Key Laboratory of Biomarker High Throughput Screening and Target Translation of Breast and Gastrointestinal Tumor, Dalian, China.

Xuren Sun (X)

Department of Gastroenterology, The First Affiliated Hospital of China Medical University, Shenyang, China.

Yuting Liu (Y)

Department of Oncology, Affiliated Zhongshan Hospital of Dalian University, China.
The Key Laboratory of Biomarker High Throughput Screening and Target Translation of Breast and Gastrointestinal Tumor, Dalian, China.

Zhi Wang (Z)

Department of Oncology, Affiliated Zhongshan Hospital of Dalian University, China.
The Key Laboratory of Biomarker High Throughput Screening and Target Translation of Breast and Gastrointestinal Tumor, Dalian, China.

Jin Yan (J)

Department of Gastrointestinal Surgery, Affiliated Zhongshan Hospital of Dalian University, China.

Xiangyu Kong (X)

Department of Gastrointestinal Surgery, Affiliated Zhongshan Hospital of Dalian University, China.

Shanshan Liang (S)

Department of Oncology, Affiliated Zhongshan Hospital of Dalian University, China.
The Key Laboratory of Biomarker High Throughput Screening and Target Translation of Breast and Gastrointestinal Tumor, Dalian, China.

Qiuge Liu (Q)

Department of Oncology, Affiliated Zhongshan Hospital of Dalian University, China.
The Key Laboratory of Biomarker High Throughput Screening and Target Translation of Breast and Gastrointestinal Tumor, Dalian, China.

Tong Zhao (T)

Department of Oncology, Affiliated Zhongshan Hospital of Dalian University, China.
The Key Laboratory of Biomarker High Throughput Screening and Target Translation of Breast and Gastrointestinal Tumor, Dalian, China.

Xuening Ji (X)

Department of Oncology, Affiliated Zhongshan Hospital of Dalian University, China.
The Key Laboratory of Biomarker High Throughput Screening and Target Translation of Breast and Gastrointestinal Tumor, Dalian, China.

Gang Wang (G)

Department of Oncology, Affiliated Zhongshan Hospital of Dalian University, China.
The Key Laboratory of Biomarker High Throughput Screening and Target Translation of Breast and Gastrointestinal Tumor, Dalian, China.

Fuguang Wang (F)

Department of Oncology, Affiliated Zhongshan Hospital of Dalian University, China.
The Key Laboratory of Biomarker High Throughput Screening and Target Translation of Breast and Gastrointestinal Tumor, Dalian, China.

Guan Wang (G)

Department of Radiology, The First Affiliated Hospital of China Medical University, Shenyang, China.

Liang Chen (L)

Department of Computer Science, College of Engineering, Shantou University, China.
Key Laboratory of Intelligent Manufacturing Technology of Ministry of Education, Shantou University, China.

Qingfu Zhang (Q)

Department of Pathology, The First Affiliated Hospital and College of Basic Medical Sciences of China Medical University, Shenyang, China.

Weipeng Lv (W)

Department of Pathology, Affiliated Zhongshan Hospital of Dalian University, China.

Heming Li (H)

Department of Oncology, Affiliated Zhongshan Hospital of Dalian University, China.
The Key Laboratory of Biomarker High Throughput Screening and Target Translation of Breast and Gastrointestinal Tumor, Dalian, China.

Mingjun Sun (M)

Department of Gastroenterology, The First Affiliated Hospital of China Medical University, Shenyang, China.
Department of Endoscopy, The First Affiliated Hospital of China Medical University, Shenyang, China.
ORCID: 0000-0001-8748-4658

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Classifications MeSH

questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Antigènes B7 › Antigène CD274 › Prognostic significance of PD-L1 expression on...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Marqueurs biologiques tumoraux › Prognostic significance of PD-L1 expression on...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Prognostic significance of PD-L1 expression on...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Prognostic significance of PD-L1 expression on...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Processus néoplasiques › Métastase tumorale › Cellules tumorales circulantes › Prognostic significance of PD-L1 expression on...
questionsmedicales.fr › Diagnostic › Pronostic › Prognostic significance of PD-L1 expression on...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies de l'estomac › Tumeurs de l'estomac › Prognostic significance of PD-L1 expression on...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du cytosquelette › Protéines de filaments intermédiaires › Vimentine › Prognostic significance of PD-L1 expression on...