Finite element analysis of bone strength in osteogenesis imperfecta.
Bone strength
Drug treatment
Finite element analysis
John Currey
Osteogenesis imperfecta
Sclerostin neutralizing antibody
Journal
Bone
ISSN: 1873-2763
Titre abrégé: Bone
Pays: United States
ID NLM: 8504048
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
19
07
2019
revised:
17
01
2020
accepted:
19
01
2020
pubmed:
26
1
2020
medline:
22
6
2021
entrez:
26
1
2020
Statut:
ppublish
Résumé
As a dedicated experimentalist, John Currey praised the high potential of finite element (FE) analysis but also recognized its critical limitations. The application of the FE methodology to bone tissue is reviewed in the light of his enthusiastic and colorful statements. In the past decades, FE analysis contributed substantially to the understanding of structure-function properties in the hierarchical organization of bone and to the simulation of bone adaptation. The systematic experimental validation of FE analysis of bone strength in anatomical locations at risk of fracture led to its application in clinical studies to evaluate efficacy of antiresorptive or anabolic treatment of bone fragility. Beyond the successful analyses of healthy or osteoporotic bone, FE analysis becomes increasingly involved in the investigation of other fragility-related bone diseases. The case of osteogenesis imperfecta (OI) is exposed, the multiscale alterations of the bone tissue and the effect of treatment summarized. A few FE analyses attempting to answer open questions in OI are then reported. An original study is finally presented that explored the structural properties of the Brtl/+ murine model of OI type IV subjected to sclerostin neutralizing antibody treatment using microFE analysis. The use of identical material properties in the four-point bending FE simulations of the femora reproduced not only the experimental values but also the statistical comparisons examining the effect of disease and treatment. Further efforts are needed to build upon the extraordinary legacy of John Currey and clarify the impact of different bone diseases on the hierarchical mechanical properties of bone.
Identifiants
pubmed: 31981754
pii: S8756-3282(20)30030-2
doi: 10.1016/j.bone.2020.115250
pmc: PMC7383936
mid: NIHMS1607412
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
115250Subventions
Organisme : NIAMS NIH HHS
ID : P30 AR069620
Pays : United States
Organisme : NIH HHS
ID : S10 OD017979
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
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