Towards Predicting Progression to Severe Dengue.
biomarkers
dengue
prognostics
transcriptomics
virus–host interactions
Journal
Trends in microbiology
ISSN: 1878-4380
Titre abrégé: Trends Microbiol
Pays: England
ID NLM: 9310916
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
received:
12
08
2019
revised:
04
11
2019
accepted:
09
12
2019
pubmed:
27
1
2020
medline:
26
5
2021
entrez:
27
1
2020
Statut:
ppublish
Résumé
There is an urgent need for prognostic assays to predict progression to severe dengue infection, which is a major global threat. While the majority of symptomatic dengue patients experience an acute febrile illness, 5-20% progress to severe infection associated with significant morbidity and mortality. Early monitoring and administration of supportive care reduce mortality and clinically usable biomarkers to predict severe dengue are needed. Here, we review recent discoveries of gene sets, anti-dengue antibody properties, and inflammatory markers with potential utility as predictors of disease progression. Upon larger scale validation and development of affordable sample-to-answer technologies, some of these biomarkers may be utilized to develop the first prognostic assay for improving patient care and allocating healthcare resources more effectively in dengue endemic countries.
Identifiants
pubmed: 31982232
pii: S0966-842X(19)30318-X
doi: 10.1016/j.tim.2019.12.003
pii:
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
478-486Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.