An Ancient BCR-like Signaling Promotes ICP Production and Hemocyte Phagocytosis in Oyster.
Biological Sciences
Cell Biology
Immunology
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
21 Feb 2020
21 Feb 2020
Historique:
received:
30
08
2019
revised:
24
11
2019
accepted:
08
01
2020
pubmed:
27
1
2020
medline:
27
1
2020
entrez:
27
1
2020
Statut:
ppublish
Résumé
BCR/TCR-based adaptive immune systems arise in the jawed vertebrates, and B cell receptors (BCRs) play an important role in the clonal selection of B cells and their differentiation into antibody-secreting plasma cells. The existence of BCR-like molecule and the activation mechanism of the downstream response are still not clear in invertebrates. In this study, an ancient BCR-like molecule (designated as CgIgR) with an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic tail was identified from the Pacific oyster Crassostrea gigas to investigate its involvement in immune response. CgIgR could bind different bacteria through five extracellular Ig domains and formed dimers. The activated CgIgR recruited CgSyk to promote CgERK phosphorylation. The CgIgR-mediated signaling promoted the production of immunoglobulin domain-containing proteins (CgICP-2 and CgLRRIG-1) through inducing CgH3K4me2. The produced CgICPs eventually facilitated hemocytes to phagocytize and eliminate V. splendidus. This study proposed that there was an ancient BCR-like molecule and BCR-like signaling in molluscs.
Identifiants
pubmed: 31982779
pii: S2589-0042(20)30017-1
doi: 10.1016/j.isci.2020.100834
pmc: PMC6994640
pii:
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100834Informations de copyright
Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Interests The authors declare no competing interests.
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