Lycopene used as Anti-inflammatory Nanodrug for the Treatment of Rheumathoid Arthritis: Animal assay, Pharmacokinetics, ABC Transporter and Tissue Deposition.
ATP-Binding Cassette Transporters
/ antagonists & inhibitors
Animals
Anti-Inflammatory Agents
/ chemistry
Arthritis, Rheumatoid
/ chemically induced
Disease Models, Animal
Dose-Response Relationship, Drug
Lycopene
/ chemistry
Male
Mice
Mice, Inbred C57BL
Nanoparticles
/ chemistry
Structure-Activity Relationship
Zymosan
Anti-Inflammatory
Arthritis
Drug
Drug resistance
Nanotechnology
Journal
Colloids and surfaces. B, Biointerfaces
ISSN: 1873-4367
Titre abrégé: Colloids Surf B Biointerfaces
Pays: Netherlands
ID NLM: 9315133
Informations de publication
Date de publication:
Apr 2020
Apr 2020
Historique:
received:
29
08
2019
revised:
06
01
2020
accepted:
18
01
2020
pubmed:
27
1
2020
medline:
24
11
2020
entrez:
27
1
2020
Statut:
ppublish
Résumé
Lycopene is a carotenoid drug that has demonstrated several properties, including antioxidant and anti-inflammatory activity. The absorption in human body is very low (10-30 % only). In order to increase the bioavailability, lycopene nanoemulsion was formulated and characterized (atomic force microscopy, thermogravimetric analysis dynamic light scattering and differential scanning calorimetry). Also in vitro assay to evaluate the at-binding with MPR1 was performed. Finally, in vivo assay in animals inducted with rheumathoid arthritis were performed. The results showed that the formulated nanolycopene had superior efficacy when compared with the conventional lycopene (not nano-formulated) in inducted animals (rheumatoid arthritis). The results support the use of nanolycopene as an anti-inflammatory agent for rheumatoid arthritis therapy.
Identifiants
pubmed: 31982791
pii: S0927-7765(20)30044-8
doi: 10.1016/j.colsurfb.2020.110814
pii:
doi:
Substances chimiques
ATP-Binding Cassette Transporters
0
Anti-Inflammatory Agents
0
Zymosan
9010-72-4
Lycopene
SB0N2N0WV6
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
110814Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.