Pharmacophore modeling of pretomanid (PA-824) derivatives for antitubercular potency against replicating and non-replicating

Mycobacterium tuberculosis LORA assay MABA assay non-replicating M. tuberculosis pharmacophore modeling pretomanid derivatives replicating M. tuberculosis virtual screening

Journal

Journal of biomolecular structure & dynamics
ISSN: 1538-0254
Titre abrégé: J Biomol Struct Dyn
Pays: England
ID NLM: 8404176

Informations de publication

Date de publication:
Feb 2021
Historique:
pubmed: 28 1 2020
medline: 29 6 2021
entrez: 28 1 2020
Statut: ppublish

Résumé

Pretomanid (PA-824) is the recently (2019) approved drug for the treatment of extensively drug-resistant (XDR) TB and the multidrug-resistant (MDR) TB by US FDA. The experimental data of antitubercular activity of 543 pretomanid derivatives (total 6 datasets) against replicating (active) and non-replicating (dormant) forms of

Identifiants

pubmed: 31983295
doi: 10.1080/07391102.2020.1719205
doi:

Substances chimiques

Antitubercular Agents 0
Nitroimidazoles 0
pretomanid 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

889-900

Auteurs

Rahul Balasaheb Aher (RB)

Combi Chem Bioresource Centre, Organic Chemistry Division (OCD), CSIR-National Chemical Laboratory, Pune, Maharashtra State, India.

Dhiman Sarkar (D)

Combi Chem Bioresource Centre, Organic Chemistry Division (OCD), CSIR-National Chemical Laboratory, Pune, Maharashtra State, India.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female
Humans United States Aged Cross-Sectional Studies Medicare Part C
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH