Female adipose tissue has improved adaptability and metabolic health compared to males in aged obesity.
Adaptation, Physiological
Adipose Tissue
/ metabolism
Adiposity
Age Factors
Aging
/ metabolism
Animals
Biomarkers
/ metabolism
Cellular Senescence
Diet, High-Fat
Energy Metabolism
Extracellular Matrix
/ metabolism
Female
Fibrosis
Immunohistochemistry
Intra-Abdominal Fat
/ metabolism
Lipid Metabolism
Lipolysis
Liver
/ immunology
Macrophages
/ immunology
Male
Mice
Obesity
/ metabolism
Sex Factors
adipose tissue macrophages
aging
extracellular matrix remodeling
senescence
sex differences
Journal
Aging
ISSN: 1945-4589
Titre abrégé: Aging (Albany NY)
Pays: United States
ID NLM: 101508617
Informations de publication
Date de publication:
26 01 2020
26 01 2020
Historique:
received:
14
08
2019
accepted:
02
01
2020
pubmed:
28
1
2020
medline:
9
1
2021
entrez:
28
1
2020
Statut:
ppublish
Résumé
Aging, like obesity, is associated with metabolic and inflammatory alterations within adipose tissue in older individuals. Younger females are protected from adipose inflammation, but older post-menopausal females exhibit exaggerated visceral adiposity correlated with increased disease risk. Obesity accelerates the onset and progression of age-associated diseases, but it is unclear if aging and obesity drive adipose tissue dysfunction in a sexually dimorphic fashion. We investigated adipose tissue metabolism and inflammation in a diet-induced obesity model in young and old mice. We identified age related sex differences in adipose tissue macrophages (ATMs), fibrosis and lipid metabolism in male and female visceral fat depot (GWAT). Although aging normalized body weights between the sexes, females remained protected from proinflammatory ATMs and stimulated lipolysis failed to adversely affect the inflammatory state even with obesity. Older obese males had augmented CD11c
Identifiants
pubmed: 31983693
doi: 10.18632/aging.102709
pii: 102709
pmc: PMC7053605
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1725-1746Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK115583
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG024824
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK089503
Pays : United States
Organisme : NIDDK NIH HHS
ID : K08 DK101755
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR002240
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK020572
Pays : United States
Références
Aging Cell. 2015 Jun;14(3):309-21
pubmed: 25720438
PLoS One. 2018 Mar 29;13(3):e0194458
pubmed: 29596429
Ageing Res Rev. 2009 Oct;8(4):339-48
pubmed: 19576300
Mol Cell Endocrinol. 2010 Jan 15;314(1):1-16
pubmed: 19682539
Diabetes. 2008 Dec;57(12):3239-46
pubmed: 18829989
Trends Endocrinol Metab. 2013 Dec;24(12):607-15
pubmed: 23988586
Nature. 2007 Jun 28;447(7148):1116-20
pubmed: 17515919
Endocrinology. 2019 Feb 1;160(2):293-312
pubmed: 30544158
Mol Metab. 2014 Jul 10;3(6):664-75
pubmed: 25161889
Gynecol Endocrinol. 2014 Jan;30(1):16-22
pubmed: 24219599
Physiol Behav. 2008 May 23;94(2):206-18
pubmed: 18037457
J Steroid Biochem Mol Biol. 2003 Sep;86(3-5):225-30
pubmed: 14623515
Biochim Biophys Acta. 2010 Sep;1801(9):1048-55
pubmed: 20435159
J Immunol. 2011 Dec 15;187(12):6208-16
pubmed: 22075699
Mol Metab. 2013 Jun 04;2(3):227-42
pubmed: 24049737
JCI Insight. 2018 Oct 4;3(19):
pubmed: 30282827
Exp Neurol. 2013 Nov;249:120-31
pubmed: 23994069
J Biol Chem. 2003 Apr 4;278(14):11888-96
pubmed: 12529376
Front Immunol. 2018 Apr 04;9:659
pubmed: 29670627
Endocr J. 2012;59(10):849-57
pubmed: 22878669
Endocr Rev. 2016 Jun;37(3):278-316
pubmed: 27159875
J Clin Invest. 2007 Jan;117(1):175-84
pubmed: 17200717
Am J Physiol Regul Integr Comp Physiol. 2016 Aug 1;311(2):R211-6
pubmed: 27252473
Diabetes Metab. 2000 Feb;26(1):12-20
pubmed: 10705099
Mediators Inflamm. 2014;2014:615917
pubmed: 25400333
Mol Med Rep. 2018 Apr;17(4):5958-5963
pubmed: 29436650
Age (Dordr). 2016 Aug;38(4):291-302
pubmed: 27578257
Nat Med. 2015 Dec;21(12):1424-35
pubmed: 26646499
Hypertension. 2008 Feb;51(2):383-92
pubmed: 18086952
J Clin Endocrinol Metab. 2005 Jul;90(7):4145-50
pubmed: 15855252
Biochim Biophys Acta. 2014 Aug;1840(8):2506-19
pubmed: 24418517
Cells. 2019 Feb 14;8(2):
pubmed: 30769840
Mol Endocrinol. 2009 Jan;23(1):11-24
pubmed: 18945811
Endocr Rev. 2002 Feb;23(1):90-119
pubmed: 11844745
Adv Exp Med Biol. 2017;1043:65-86
pubmed: 29224091
J Clin Invest. 2010 Oct;120(10):3466-79
pubmed: 20877011
Menopause. 2001 Jul-Aug;8(4):266-73
pubmed: 11449084
Am J Physiol Endocrinol Metab. 2005 Oct;289(4):E608-16
pubmed: 15941787
Eur J Nutr. 2012 Oct;51(7):861-70
pubmed: 22042005
Curr Diab Rep. 2018 Jul 30;18(9):69
pubmed: 30058013
Cardiovasc Res. 2017 Jul 1;113(9):1009-1023
pubmed: 28838042
Arch Intern Med. 2009 Oct 26;169(19):1762-6
pubmed: 19858433
Hum Reprod Update. 2010 Jul-Aug;16(4):347-63
pubmed: 20159883
Neurology. 2007 Nov 13;69(20):1898-904
pubmed: 17581944
Nat Rev Immunol. 2011 Feb;11(2):85-97
pubmed: 21252989
J Neuroimmunol. 2010 Feb 26;219(1-2):90-9
pubmed: 20096467
J Hepatol. 2016 May;64(5):1167-1175
pubmed: 26780287
Mol Cell Endocrinol. 2009 Feb 5;299(1):2-13
pubmed: 19059459
J Invest Dermatol. 2007 Nov;127(11):2645-55
pubmed: 17554369
J Biol Chem. 2015 May 22;290(21):13250-62
pubmed: 25869128
Trends Genet. 2004 Jan;20(1):33-43
pubmed: 14698617
Proc Natl Acad Sci U S A. 2000 Nov 7;97(23):12735-40
pubmed: 11070087
Placenta. 2008 Mar;29(3):274-81
pubmed: 18262644
Biochem J. 2002 Jun 15;364(Pt 3):739-46
pubmed: 12049638
Nat Rev Endocrinol. 2014 Oct;10(10):624-36
pubmed: 25022814
Climacteric. 2012 Oct;15(5):419-29
pubmed: 22978257
Life Sci. 1994;54(18):1305-12
pubmed: 8190002
Cell Metab. 2008 Jun;7(6):496-507
pubmed: 18522831
Maturitas. 2010 May;66(1):16-22
pubmed: 20153946
Maturitas. 2001 Jan 31;37(3):173-9
pubmed: 11173179