Therapeutic hypothermia for acute ischaemic stroke. Results of a European multicentre, randomised, phase III clinical trial.

Ischaemic stroke cooling hypothermia randomised trial treatment

Journal

European stroke journal
ISSN: 2396-9881
Titre abrégé: Eur Stroke J
Pays: England
ID NLM: 101688446

Informations de publication

Date de publication:
Sep 2019
Historique:
received: 30 11 2018
accepted: 27 02 2019
entrez: 28 1 2020
pubmed: 28 1 2020
medline: 28 1 2020
Statut: ppublish

Résumé

We assessed whether modest systemic cooling started within 6 hours of symptom onset improves functional outcome at three months in awake patients with acute ischaemic stroke. In this European randomised open-label clinical trial with blinded outcome assessment, adult patients with acute ischaemic stroke were randomised to cooling to a target body temperature of 34.0-35.0°C, started within 6 h after stroke onset and maintained for 12 or 24 h , versus standard treatment. The primary outcome was the score on the modified Rankin Scale at 91 days, as analysed with ordinal logistic regression. The trial was stopped after inclusion of 98 of the originally intended 1500 patients because of slow recruitment and cessation of funding. Forty-nine patients were randomised to hypothermia versus 49 to standard treatment. Four patients were lost to follow-up. Of patients randomised to hypothermia, 15 (31%) achieved the predefined cooling targets. The primary outcome did not differ between the groups (odds ratio for good outcome, 1.01; 95% confidence interval, 0.48-2.13; In this trial, cooling to a target of 34.0-35.0°C and maintaining this for 12 or 24 h was not feasible in the majority of patients. The final sample was underpowered to detect clinically relevant differences in outcomes. Before new trials are launched, the feasibility of cooling needs to be improved.

Identifiants

pubmed: 31984233
doi: 10.1177/2396987319844690
pii: 10.1177_2396987319844690
pmc: PMC6960691
doi:

Types de publication

Journal Article

Langues

eng

Pagination

254-262

Subventions

Organisme : Medical Research Council
ID : G0300623
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0400069
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_G1002455
Pays : United Kingdom

Informations de copyright

© European Stroke Organisation 2019.

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Auteurs

H Bart van der Worp (HB)

Department of Neurology and Neurosurgery, Brain Center, University Medical Center Utrecht, Utrecht, The Netherlands.

Malcolm R Macleod (MR)

Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, Scotland, UK.

Philip Mw Bath (PM)

Stroke Trials Unit, Division of Clinical Neuroscience, University of Nottingham, Nottingham, UK.

Raj Bathula (R)

Stroke Department, Northwick Park Hospital, London, UK.

Hanne Christensen (H)

Department of Neurology, Bispebjerg og Frederiksberg Hospitaler, University of Copenhagen, Copenhagen, Denmark.

Bridget Colam (B)

Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, Scotland, UK.

Charlotte Cordonnier (C)

University of Lille, Inserm U1171, Degenerative and Vascular Cognitive Disorders, Centre Hospitalier Universitaire Lille, Lille, France.

Jacques Demotes-Mainard (J)

ECRIN, Paris, France.

Isabelle Durand-Zaleski (I)

APHP URCEco, University Paris Est Creteil & INSERM UMR 1123, Paris, France.

Christian Gluud (C)

Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

Janus Christian Jakobsen (JC)

Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
Department of Cardiology, Holbæk Hospital, Copenhagen, Denmark.

Bernd Kallmünzer (B)

Department of Neurology, University Medical Centre Erlangen, Erlangen, Germany.

Rainer Kollmar (R)

Klinik für Neurologie und Neurointensivmedizin, Klinikum Darmstadt, Darmstadt, Germany.

Derk W Krieger (DW)

Mediclinic Middle East, Dubai, UAE.

Kennedy R Lees (KR)

School of Medicine, Dentistry & Nursing, University of Glasgow, Glasgow, UK.

Dominik Michalski (D)

Department of Neurology, University of Leipzig, Leipzig, Germany.

Carlos Molina (C)

Hospital Universitari Vall d´Hebron, Barcelona, Spain.

Joan Montaner (J)

Neurovascular Research Laboratory, Vall d'Hebron Research Institute, Barcelona, Spain.

Risto O Roine (RO)

Division of Clinical Neurosciences, Turku University Hospital and University of Turku, Turku, Finland.

Jesper Petersson (J)

Department of Neurology, Skane University Hospital, Malmö, Sweden.

Richard Perry (R)

Stroke Service, National Hospital for Neurology & Neurosurgery, Queen Square, London, UK.

Nikola Sprigg (N)

Stroke Trials Unit, Division of Clinical Neuroscience, University of Nottingham, Nottingham, UK.

Dimitre Staykov (D)

Department of Neurology, University Medical Centre Erlangen, Erlangen, Germany.
Department of Neurology, Hospital of the Brothers of St. John, Eisenstadt, Austria.

Istvan Szabo (I)

European Stroke Research Network for Hypothermia, Brussels, Belgium.

Geert Vanhooren (G)

AZ Sint-Jan Brugge-Oostende, Brugge, Belgium AV.

Joanna M Wardlaw (JM)

Edinburgh Imaging, Centre for Clinical Brain Sciences and UK Dementia Research Institute, University of Edinburgh, Edinburgh, UK.

Per Winkel (P)

Copenhagen Trial Unit, Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

Stefan Schwab (S)

Department of Neurology, University Medical Centre Erlangen, Erlangen, Germany.

Classifications MeSH