Solvent-mediated Highly Efficient Synthesis of [1,2,4]triazolo/benzimidazoloquinazolinone Derivatives.
Fluorinated alcohols
anticancer
green chemistry
heterocyclic
multicomponent
triazole
Journal
Current organic synthesis
ISSN: 1570-1794
Titre abrégé: Curr Org Synth
Pays: United Arab Emirates
ID NLM: 101208457
Informations de publication
Date de publication:
2019
2019
Historique:
received:
02
07
2019
revised:
03
09
2019
accepted:
01
10
2019
entrez:
28
1
2020
pubmed:
28
1
2020
medline:
28
1
2020
Statut:
ppublish
Résumé
An efficient and catalyst-free procedure for the synthesis of [1,2,4]triazolo/benzimidazolo quinazolinones has been developed in 2,2,2-trifluoroethanol or deep eutectic solvent(DESs) as a clean reaction media. All of the obtained products are known compounds and identified by IR, 1HNMR,13CNMR, and melting points. Various products were obtained in good to excellent yields under reaction conditions. We have efficiently developed a practical and catalyst-free approach for the synthesis of [1,2,4]triazolo/benzimidazolo quinazolinones employing TFE as a clean and reusable media.
Identifiants
pubmed: 31984925
pii: COS-EPUB-101618
doi: 10.2174/1570179416666191018145142
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1185-1190Informations de copyright
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