How molecular allergology can shape the management of allergic airways diseases.
Journal
Current opinion in allergy and clinical immunology
ISSN: 1473-6322
Titre abrégé: Curr Opin Allergy Clin Immunol
Pays: United States
ID NLM: 100936359
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
pubmed:
28
1
2020
medline:
16
6
2021
entrez:
28
1
2020
Statut:
ppublish
Résumé
In allergy, personalized medicine passes through the assessment of molecular allergens sensitization profiles. Such technique may help to better diagnose and treat patients suffering from allergic respiratory diseases. Different laboratory tests are available today to assess sensitization to molecular allergens, from singleplex assays, to unspecific, screening multiplex assays, mainly performed through microarrays or macroarrays. It is important to collect both results from specific IgE toward allergen extracts and toward molecular allergens, to collect the most complete information on the patient's profile, and therefore to highlight genuine sensitization, and exclude cross-reaction and sensitization because of pan-allergens. Being able to know the exact molecular sensitization profile of the patient, also helps predicting the possible evolution of the disease, and targeting the most appropriate allergen immunotherapy treatment to prescribe. Even though a cost-effective analysis of running multiple assays in allergic patients has not been performed yet, such technique proved to be more efficient in detecting the appropriate treatment in each patient and in analyzing the true sensitization profile in patients suffering from allergic rhinitis, conjunctivitis, and asthma.
Identifiants
pubmed: 31985547
doi: 10.1097/ACI.0000000000000630
pii: 00130832-202004000-00011
doi:
Substances chimiques
Allergens
0
Immunoglobulin E
37341-29-0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
149-154Références
Bousquet J, Anto JM, Demoly P, et al. WHO Collaborating Center for Asthma and Rhinitis. Severe chronic allergic (and related) diseases: a uniform approach--a MeDALL--GA2LEN--ARIA position paper. Int Arch Allergy Immunol 2012; 158:216–231.
Small P, Keith PK, Kim H. Allergic rhinitis. Allergy Asthma Clin Immunol 2018; 14: (Suppl 2): 51.
Til-Pérez G, Carnevale C, Sarría-Echegaray PL, et al. Sensitization profile in patients with respiratory allergic diseases: differences between conventional and molecular diagnosis (a cross-sectional study). Clin Mol Allergy 2019; 17:8.
Matricardi PM, Kleine-Tebbe J, Hoffmann HJ, et al. EAACI molecular allergology user's guide. Pediatr Allergy Immunol 2016; 27: (Suppl 23): 1–250.
Matricardi PM, Dramburg S, Potapova E, et al. Molecular diagnosis for allergen immunotherapy. J Allergy Clin Immunol 2019; 143:831–843.
Del-Río Camacho G, Montes Arjona AM, Fernández-Cantalejo Padial J, et al. How molecular diagnosis may modify immunotherapy prescription in multisensitized pollen-allergic children. Allergol Immunopathol (Madr) 2018; 46:552–556.
Heffler E, Puggioni F, Descalzi D, et al. Microarray immunodiagnostics for aeroallergens. Curr Allergy Asthma Rep 2019; 19:10.
Roberts G, Pfaar O, Akdis CA, et al. EAACI guidelines on allergen immunotherapy: allergic rhinoconjunctivitis. Allergy 2018; 73:765–798.
Martínez-Cañavate Burgos A, Torres-Borrego J, Molina Terán AB, et al. Molecular sensitization patterns and influence of molecular diagnosis in immunotherapy prescription in children sensitized to both grass and olive pollen. Pediatr Allergy Immunol 2018; 29:369–374.
Belhassen M, Demoly P, Bloch-Morot E, et al. Costs of perennial allergic rhinitis and allergic asthma increase with severity and poor disease control. Allergy 2017; 72:948–958.
Linneberg A, Dam Petersen K, Hahn-Pedersen J, et al. Burden of allergic respiratory disease: a systematic review. Clin Mol Allergy 2016; 14:12.
Matricardi PM, Dramburg S, Skevaki C, Renz H. ‘Molecular extracts’ for allergy diagnostics and therapy. Pediatr Allergy Immunol 2019; 30:55–58.
Melioli G, Puggioni F, Racca F, et al. Clinical outcomes related to molecular allergy diagnosis. Curr Opin Allergy Clin Immunol 2019; 19:204–208.
Mothes-Luksch N, Jordakieva G, Hinterhölzl L, et al. Allergy diagnosis from symptoms to molecules, or from molecules to symptoms: a comparative clinical study. World Allergy Organ J 2018; 11:22.
Nwaru BI, Suzuki S, Ekerljung L, et al. Furry animal allergen component sensitization and clinical outcomes in adult asthma and rhinitis. J Allergy Clin Immunol Pract 2019; 7:1230–1238.e4.
Cipriani F, Tripodi S, Panetta V, et al. Early molecular biomarkers predicting the evolution of allergic rhinitis and its comorbidities: a longitudinal multicenter study of a patient cohort. Pediatr Allergy Immunol 2019; 30:325–334.
Douladiris N, Garib V, Piskou K, et al. Molecular allergy diagnosis: a potential tool for the assessment of severity of grass pollen-induced rhinitis in children. Pediatr Allergy Immunol 2019; 30:852–855.
Posa D, Perna S, Resch Y, et al. Evolution and predictive value of IgE responses toward a comprehensive panel of house dust mite allergens during the first 2 decades of life. J Allergy Clin Immunol 2017; 139:541–549.e8.
Hatzler L, Panetta V, Lau S, et al. Molecular spreading and predictive value of preclinical IgE response to Phleum pratense in children with hay fever. J Allergy Clin Immunol 2012; 130:894–901.e5.
Tosca MA, Licari A, Olcese R, et al. Immunotherapy and asthma in children. Front Pediatr 2018; 6:231.
Richter AK, Klimek L, Merk HF, et al. Impact of increasing treatment rates on cost-effectiveness of subcutaneous immunotherapy (SCIT) in respiratory allergy: a decision analytic modelling approach. Eur J Health Econ 2018; 19:1229–1242.
Agache I, Lau S, Akdis CA, et al. EAACI guidelines on allergen immunotherapy: house dust mite-driven allergic asthma. Allergy 2019; 74:855–873.
Zubchenko S, Sharikadze O, Maruniak S. Allergen component testing: a new era in diagnostics of patients with pollen allergy. Wiad Lek 2019; 72:391–394.
Stringari G, Tripodi S, Caffarelli C, et al. The effect of component-resolved diagnosis on specific immunotherapy prescription in children with hay fever. J Allergy Clin Immunol 2014; 134:75–81.
Passalacqua G, Landi M, Peroni DG. Allergen immunotherapy for pediatric asthma: current evidence and knowledge gaps. Curr Opin Allergy Clin Immunol 2020; 20:162–167.